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• W2765461106 startingPage "565" @default.
• W2765461106 abstract "Muconic acid is a promising platform biochemical and precursor to adipic acid, which can be used to synthesize various plastics and polymers. In this study, the systematic construction and comparative evaluation of a modular network of non-natural pathways for muconic acid biosynthesis was investigated in Escherichia coli, including via three distinct and novel pathways proceeding via phenol as a common intermediate. However, poor recombinant activity and high promiscuity of phenol hydroxylase ultimately limited phenol-dependent muconic acid production. A fourth pathway proceeding via p-hydroxybenzoate, protocatechuate, and catechol was accordingly developed, though with muconic acid titers by this route reaching just 819 mg/L, its performance lagged behind that of the established, 3-dehydroshikimiate-derived route. Finally, these two most promising pathways were coexpressed in parallel to create a synthetic metabolic funnel that, by enabling maximal net precursor assimilation and flux while preserving native chorismate biosynthesis, nearly doubled muconic acid production to up to >3.1 g/L at a glucose yield of 158 mg/g while introducing only a single auxotrophy. This generalizable, funneling strategy is expected to have broad applications in metabolic engineering for further enhancing production of muconic acid, as well as other important bioproducts of interest." @default.
• W2765461106 created "2017-11-10" @default.
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• W2765461106 date "2017-11-02" @default.
• W2765461106 modified "2023-09-24" @default.
• W2765461106 title "Muconic Acid Production <i>via</i> Alternative Pathways and a Synthetic “Metabolic Funnel”" @default.
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• W2765461106 doi "https://doi.org/10.1021/acssynbio.7b00331" @default.
• W2765461106 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29053259" @default.
• W2765461106 hasPublicationYear "2017" @default.
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