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- W2765473993 abstract "The pathophysiological changes preceding most dementias begin decades before the onset of symptoms which suggests that important risk factors may act relatively early in the life course. Pulmonary function, which is a proxy for multiple insults across the life course including smoking, illness, and socioeconomic deprivation, is therefore a potential risk factor for later dementia. In this article we review the best evidence, taken from longitudinal studies, for an association of pulmonary function and respiratory disease with dementia. We searched relevant articles by March 2016 from PubMed and, where possible, pooled study-specific results in random effects meta-analyses. From 408 search results, we included ten studies of pulmonary function and dementia and eight studies of respiratory illness and dementia. Comparing the lowest quartile of forced expiratory volume in one second (FEV1) with the highest resulted in a doubling of dementia risk (meta-analysed hazard ratio 2.02, 95% confidence interval 1.23–3.33). Findings for forced vital capacity (FVC) and peak expiratory flow (PEF) were comparable. The presence of respiratory illness was also associated with an increased risk of incident dementia (meta-analysed hazard ratio 1.62, 95% confidence interval 1.32–1.98). These significant effect estimates are promising for future development in prevention strategies related to pulmonary function, but further research is needed to determine whether the excess risk results from the adverse effects on the brain's oxygen supply; that low pulmonary function serves as a ‘record’ of life course exposures; or marks shared aetiology between pulmonary and cardiovascular diseases." @default.
- W2765473993 created "2017-11-10" @default.
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- W2765473993 date "2017-07-01" @default.
- W2765473993 modified "2023-09-27" @default.
- W2765473993 title "[P4-351]: PULMONARY FUNCTION AND RISK OF DEMENTIA: A SYSTEMATIC REVIEW WITH META-ANALYSIS" @default.
- W2765473993 doi "https://doi.org/10.1016/j.jalz.2017.06.2222" @default.
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