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• W2765488733 abstract "Secretory and transmembrane proteins undergo post-translational modifications and folding in the subcellular organelle, that is, endoplasmic reticulum (ER) to become functionally active. Various factors such as high oxidative stress, low glucose, calcium imbalance, and viral infections interfere with the ER protein folding functions, leading to accumulation of unfolded and misfolded proteins that activate downstream signal transduction pathways, termed as unfolded protein response (UPR). This UPR signaling is adaptive and restored the normal function of cells by decreasing protein synthesis, increasing the folding capacity of ER and degradation of misfolded proteins. If the stress condition is overwhelmed, then UPR signaling shifts to apoptotic pathways. However, cancer cells utilized these UPR signaling for their survival and progression as an adaptive mechanism. In this review, the authors discuss about the overview of ER stress and subsequent UPR signaling and various aspects of cancer as survival, proliferation, and angiogenesis in relation to UPR. Understanding the UPR signaling in relation to cancer will be further helpful in designing therapeutics against cancer." @default.
• W2765488733 created "2017-11-10" @default.
• W2765488733 creator A5051570299 @default.
• W2765488733 date "2017-10-01" @default.
• W2765488733 modified "2023-09-26" @default.
• W2765488733 title "An Overview of Unfolded Protein Response Signaling and Its Role in Cancer" @default.
• W2765488733 cites W1493048246 @default.
• W2765488733 cites W1666371634 @default.
• W2765488733 cites W1672219033 @default.
• W2765488733 cites W1697178647 @default.
• W2765488733 cites W1905806846 @default.
• W2765488733 cites W1969809609 @default.
• W2765488733 cites W1970198745 @default.
• W2765488733 cites W1972482541 @default.
• W2765488733 cites W1974191631 @default.
• W2765488733 cites W1974740818 @default.
• W2765488733 cites W1976161806 @default.
• W2765488733 cites W1977603207 @default.
• W2765488733 cites W1977991884 @default.
• W2765488733 cites W1978493656 @default.
• W2765488733 cites W1984547206 @default.
• W2765488733 cites W1987897718 @default.
• W2765488733 cites W1990363097 @default.
• W2765488733 cites W1990425294 @default.
• W2765488733 cites W1998750778 @default.
• W2765488733 cites W2001399725 @default.
• W2765488733 cites W2002644660 @default.
• W2765488733 cites W2007954304 @default.
• W2765488733 cites W2008055344 @default.
• W2765488733 cites W2010645035 @default.
• W2765488733 cites W2015780669 @default.
• W2765488733 cites W2016000163 @default.
• W2765488733 cites W2019055460 @default.
• W2765488733 cites W2023568503 @default.
• W2765488733 cites W2025846979 @default.
• W2765488733 cites W2026642838 @default.
• W2765488733 cites W2030267305 @default.
• W2765488733 cites W2030739080 @default.
• W2765488733 cites W2034213169 @default.
• W2765488733 cites W2038291983 @default.
• W2765488733 cites W2038600646 @default.
• W2765488733 cites W2039689649 @default.
• W2765488733 cites W2040827479 @default.
• W2765488733 cites W2042391634 @default.
• W2765488733 cites W2048399342 @default.
• W2765488733 cites W2052645281 @default.
• W2765488733 cites W2053442171 @default.
• W2765488733 cites W2053470799 @default.
• W2765488733 cites W2053543069 @default.
• W2765488733 cites W2058785552 @default.
• W2765488733 cites W2062473455 @default.
• W2765488733 cites W2066379425 @default.
• W2765488733 cites W2066606787 @default.
• W2765488733 cites W2067669315 @default.
• W2765488733 cites W2069426988 @default.
• W2765488733 cites W2069924169 @default.
• W2765488733 cites W2074802590 @default.
• W2765488733 cites W2075115412 @default.
• W2765488733 cites W2079944569 @default.
• W2765488733 cites W2080666240 @default.
• W2765488733 cites W2083658462 @default.
• W2765488733 cites W2084944302 @default.
• W2765488733 cites W2085700442 @default.
• W2765488733 cites W2085966620 @default.
• W2765488733 cites W2089198803 @default.
• W2765488733 cites W2093535002 @default.
• W2765488733 cites W2106314483 @default.
• W2765488733 cites W2108550486 @default.
• W2765488733 cites W2111326065 @default.
• W2765488733 cites W2125262828 @default.
• W2765488733 cites W2126530235 @default.
• W2765488733 cites W2127453231 @default.
• W2765488733 cites W2127848114 @default.
• W2765488733 cites W2128489958 @default.
• W2765488733 cites W2129695436 @default.
• W2765488733 cites W2139568257 @default.
• W2765488733 cites W2144065739 @default.
• W2765488733 cites W2148149623 @default.
• W2765488733 cites W2152354289 @default.
• W2765488733 cites W2154816100 @default.
• W2765488733 cites W2156615060 @default.
• W2765488733 cites W2157515789 @default.
• W2765488733 cites W2159466552 @default.
• W2765488733 cites W2162695817 @default.
• W2765488733 cites W2273902252 @default.
• W2765488733 cites W2402980636 @default.
• W2765488733 cites W2520532243 @default.
• W2765488733 cites W2546671354 @default.
• W2765488733 cites W2953000594 @default.
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• W2765488733 doi "https://doi.org/10.1089/cbr.2017.2309" @default.
• W2765488733 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29053418" @default.
• W2765488733 hasPublicationYear "2017" @default.
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