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- W2765488740 abstract "Exposure to life stressors exacerbates gastrointestinal conditions, including inflammatory bowel diseases and irritable bowel syndrome, however the mechanisms by which this occurs have remained elusive. It is known that stressor exposure significantly alters the intestinal microbiota, which leads to dysregulated colonic inflammatory responses upon pathogen challenge. The link between stressor-induced microbial changes and the resulting enhanced immune response is not known, but colonic epithelial cells (CECs) are thought to be involved. We determined whether stressor exposure led to aberrant CEC signaling. Mice were exposed to social disruption (SDR), involving repeated social defeat for 2 h a night on 6 consecutive nights. The morning following the last night of SDR, the colonic microbiome was assessed using 16s rRNA gene sequencing. Colons were also excised for CEC isolation, purification, and RNA extraction for next generation RNA sequencing (RNAseq) to characterize the CEC transcriptome profile. Results demonstrated that CECs are highly active during SDR-exposure as evidenced by significant changes in over 500 genes, including increases in antimicrobial peptides, e.g., RegIIIgamma, inflammatory mediators, e.g., iNOS, TNF signaling, and serum amyloid A, and chemokines, e.g., CXCL2. Significant increases in genes such as Duox, known to be induced by microbial dysbiosis, support the hypothesis that stressor-induced microbial changes contribute to dysregulation of CEC activity. Increased transcription of inflammation-related genes indicates that CEC play a role in stressor-induced exacerbation of colonic inflammation." @default.
- W2765488740 created "2017-11-10" @default.
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- W2765488740 date "2017-11-01" @default.
- W2765488740 modified "2023-09-26" @default.
- W2765488740 title "The colonic epithelial transcriptome and intestinal microbiome are significantly changed by social stressor exposure" @default.
- W2765488740 doi "https://doi.org/10.1016/j.bbi.2017.07.069" @default.
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