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• W2765499569 abstract "Abstract The aim of this study was to improve the pharmaceutical properties of theobromine (TB), particularly its flowability and dissolution rate, by preparing solid dispersions using different technologies (hot melt extrusion—HME, freeze-drying—FD, and supercritical fluid—SF) as well as testing different hydrophilic polymeric matrixes (Eudragit™ E, Plasdone™ S and Soluplus™). Samples were characterized by means of physicochemical assays, along with flow measurements and determination of dissolution profiles. X-ray diffraction data revealed the maintenance of original drug crystalline phase in all solid dispersions produced, nevertheless thermal and spectroscopy assays evidenced drug–polymer interactions, especially for samples produced using HME. The drug content was preserved after processing and no signal of decomposition or instability was verified. Pharmaceutical performance of solid dispersions was markedly influenced by the processing method. Systems obtained using HME were distinguished by having better flowability (angle of spatula 70%). In conclusion, the increasing of TB functional properties could bring good perspectives of bioavailability enhancement with prospects of broadening this drug insertion into the pharmaceutical market." @default.
• W2765499569 created "2017-11-10" @default.
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• W2765499569 date "2018-04-01" @default.
• W2765499569 modified "2023-10-18" @default.
• W2765499569 title "Improvements of theobromine pharmaceutical properties using solid dispersions prepared with newfound technologies" @default.
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• W2765499569 doi "https://doi.org/10.1016/j.cherd.2017.10.019" @default.
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