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- W2765508745 abstract "Undisclosed exploitation of flexibility in data acquisition and analysis blurs the important distinction between exploratory and hypothesis-driven findings and inflates false-positive rates 1–4 . Indeed, recent replication attempts have revealed low levels of replicability, pointing to high rates of false-positives in the literature 5–10 . A contemporary solution to this problem is pre-registration: commitment to aspects of methods and analysis before data acquisition 11 . This solution is valid only to the extent that the commitment stage is time-locked to precede data collection. To date, time-locking can only be guaranteed by introducing a third party such as peer reviewers at an early stage, making this solution less appealing for many 12 . Here we adapt a cryptographic method 13 to encode information of study protocol within random aspects of the data acquisition process. This way, the structure of variability in the data time-locks the commitment stage with respect to data acquisition. Being independent of any third party, this method fully preserves scientific autonomy and confidentiality. We provide code for easy implementation and a detailed example from the field of functional Magnetic Resonance Imaging (fMRI)." @default.
- W2765508745 created "2017-11-10" @default.
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- W2765508745 date "2017-11-04" @default.
- W2765508745 modified "2023-09-24" @default.
- W2765508745 title "Using experimental data as a voucher for study pre-registration" @default.
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- W2765508745 doi "https://doi.org/10.1101/213439" @default.
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