Matches in SemOpenAlex for { <https://semopenalex.org/work/W2765514987> ?p ?o ?g. }
- W2765514987 endingPage "332" @default.
- W2765514987 startingPage "332" @default.
- W2765514987 abstract "4,5,6,7-Tetrabromo-1H-benzotriazole (TBBT) is still considered a reference inhibitor of casein kinase II (CK2), a valuable target for anticancer therapy, even though the poor solubility in water of this active pharmaceutical ingredient (API) has prevented its implementation in therapy. We decided to explore the interactions preferentially formed by TBBT in crystalline solids in order to obtain information helpful for the development of new TBBT cocrystals possibly endowed with improved bioavailability. In this paper, we describe the synthesis and the structural characterization of the TBBT methanol solvate and of the TBBT salt with N,N,N’,N’-tetramethylethylenediamine. It is shown that TBBT can give rise to several competing interactions. This API is clearly a good halogen bond (XB) donor, with bromine atoms adjacent to the triazole ring possibly better donors than the two others. TBBT is also a good hydrogen bond (HB) donor, with the triazole hydrogen forming an HB with the acceptor or being transferred to it. Interestingly, one of the triazole nitrogens was proven to be able to work as a hydrogen bond acceptor." @default.
- W2765514987 created "2017-11-10" @default.
- W2765514987 creator A5003569543 @default.
- W2765514987 creator A5014724308 @default.
- W2765514987 creator A5047779076 @default.
- W2765514987 creator A5054773329 @default.
- W2765514987 creator A5081562507 @default.
- W2765514987 date "2017-10-31" @default.
- W2765514987 modified "2023-09-25" @default.
- W2765514987 title "Halogen and Hydrogen Bonding in Multicomponent Crystals of Tetrabromo-1H-Benzotriazole" @default.
- W2765514987 cites W1967985359 @default.
- W2765514987 cites W1968943086 @default.
- W2765514987 cites W1972361002 @default.
- W2765514987 cites W1976195995 @default.
- W2765514987 cites W1978517331 @default.
- W2765514987 cites W1993148712 @default.
- W2765514987 cites W1999956312 @default.
- W2765514987 cites W2001454290 @default.
- W2765514987 cites W2011134011 @default.
- W2765514987 cites W2011219963 @default.
- W2765514987 cites W2016011980 @default.
- W2765514987 cites W2020722862 @default.
- W2765514987 cites W2021995177 @default.
- W2765514987 cites W2022398543 @default.
- W2765514987 cites W2030217410 @default.
- W2765514987 cites W2041302869 @default.
- W2765514987 cites W2047862325 @default.
- W2765514987 cites W2062323422 @default.
- W2765514987 cites W2063334178 @default.
- W2765514987 cites W2063967033 @default.
- W2765514987 cites W2073911984 @default.
- W2765514987 cites W2078641649 @default.
- W2765514987 cites W2082753156 @default.
- W2765514987 cites W2087843219 @default.
- W2765514987 cites W2088632075 @default.
- W2765514987 cites W2088938650 @default.
- W2765514987 cites W2094269321 @default.
- W2765514987 cites W2094742663 @default.
- W2765514987 cites W2108805958 @default.
- W2765514987 cites W2131214655 @default.
- W2765514987 cites W2131350133 @default.
- W2765514987 cites W2144211472 @default.
- W2765514987 cites W2144332006 @default.
- W2765514987 cites W2157104529 @default.
- W2765514987 cites W2160842779 @default.
- W2765514987 cites W2166344128 @default.
- W2765514987 cites W2265596863 @default.
- W2765514987 cites W2330883182 @default.
- W2765514987 cites W2335434301 @default.
- W2765514987 cites W2537476119 @default.
- W2765514987 cites W2951127902 @default.
- W2765514987 cites W4239000727 @default.
- W2765514987 doi "https://doi.org/10.3390/cryst7110332" @default.
- W2765514987 hasPublicationYear "2017" @default.
- W2765514987 type Work @default.
- W2765514987 sameAs 2765514987 @default.
- W2765514987 citedByCount "6" @default.
- W2765514987 countsByYear W27655149872019 @default.
- W2765514987 countsByYear W27655149872020 @default.
- W2765514987 countsByYear W27655149872022 @default.
- W2765514987 countsByYear W27655149872023 @default.
- W2765514987 crossrefType "journal-article" @default.
- W2765514987 hasAuthorship W2765514987A5003569543 @default.
- W2765514987 hasAuthorship W2765514987A5014724308 @default.
- W2765514987 hasAuthorship W2765514987A5047779076 @default.
- W2765514987 hasAuthorship W2765514987A5054773329 @default.
- W2765514987 hasAuthorship W2765514987A5081562507 @default.
- W2765514987 hasBestOaLocation W27655149871 @default.
- W2765514987 hasConcept C108204754 @default.
- W2765514987 hasConcept C112887158 @default.
- W2765514987 hasConcept C121332964 @default.
- W2765514987 hasConcept C155574463 @default.
- W2765514987 hasConcept C155647269 @default.
- W2765514987 hasConcept C178790620 @default.
- W2765514987 hasConcept C185592680 @default.
- W2765514987 hasConcept C21951064 @default.
- W2765514987 hasConcept C23029723 @default.
- W2765514987 hasConcept C26873012 @default.
- W2765514987 hasConcept C2777844968 @default.
- W2765514987 hasConcept C2777907353 @default.
- W2765514987 hasConcept C2779892579 @default.
- W2765514987 hasConcept C2780263894 @default.
- W2765514987 hasConcept C32909587 @default.
- W2765514987 hasConcept C46062151 @default.
- W2765514987 hasConcept C517835270 @default.
- W2765514987 hasConcept C8010536 @default.
- W2765514987 hasConceptScore W2765514987C108204754 @default.
- W2765514987 hasConceptScore W2765514987C112887158 @default.
- W2765514987 hasConceptScore W2765514987C121332964 @default.
- W2765514987 hasConceptScore W2765514987C155574463 @default.
- W2765514987 hasConceptScore W2765514987C155647269 @default.
- W2765514987 hasConceptScore W2765514987C178790620 @default.
- W2765514987 hasConceptScore W2765514987C185592680 @default.
- W2765514987 hasConceptScore W2765514987C21951064 @default.
- W2765514987 hasConceptScore W2765514987C23029723 @default.
- W2765514987 hasConceptScore W2765514987C26873012 @default.
- W2765514987 hasConceptScore W2765514987C2777844968 @default.
- W2765514987 hasConceptScore W2765514987C2777907353 @default.