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• W2765531693 abstract "Brachyspira hampsonii causes dysentery-like disease in infected pigs. Serial passage of a virulent swine isolate (P13) one-hundred times in laboratory culture medium was conducted to produce an attenuated strain, and to identify genomic determinants of virulence through comparison of genome sequences of the original and passaged strains. The resulting strain, P113, did not differ from P13 in terms of diagnostic biochemical characteristics but had an enhanced growth rate in culture, indicating laboratory adaptation. Whole genome sequencing of P113 revealed several single-nucleotide changes including a T to C transition that results in an R to G amino acid change in a putative mannose-1-phosphate guanylytransferase that is implicated in production of lipo-oligosaccharide. P113 was partially attenuated in a mouse model of infection, indicated by significantly fewer observations of abnormal feces in mice infected with P113 relative to P13. No differences were detected in bacterial shedding in feces, demonstrating that the ability of the organism to colonize mice was not affected. Passage through a mouse did not further alter the virulence of P113. Results of this study provide insight into genomic determinants of virulence in B. hampsonii and a live attenuated vaccine candidate." @default.
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• W2765531693 date "2017-10-24" @default.
• W2765531693 modified "2023-10-17" @default.
• W2765531693 title "In vitro attenuation of a virulent swine isolate of Brachyspira hampsonii" @default.
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• W2765531693 doi "https://doi.org/10.1093/femspd/ftx116" @default.
• W2765531693 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29069340" @default.
• W2765531693 hasPublicationYear "2017" @default.
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