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- W2765553020 abstract "Abstract The gut microbiome and lipid metabolism are both recognized as essential components in the maintenance of metabolic health. The mechanisms involved are multifactorial and (especially for microbiome) poorly defined. A strategic approach to investigate the complexity of the microbial influence on lipid metabolism would facilitate determination of relevant molecular mechanisms for microbiome-targeted therapeutics. E. coli is associated with obesity and metabolic syndrome and we used this association in conjunction with gnotobiotic models to investigate the impact of E. coli on lipid metabolism. To address the complexities of the integration of the microbiome and lipid metabolism, we developed transcriptomics-driven lipidomics (TDL) to predict the impact of E. coli colonization on lipid metabolism and established mediators of inflammation and insulin resistance including arachidonic acid metabolism, alterations in bile acids and dietary lipid absorption. A microbiome-related therapeutic approach targeting these mechanisms may therefore provide a therapeutic avenue supporting maintenance of metabolic health." @default.
- W2765553020 created "2017-11-10" @default.
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- W2765553020 date "2017-11-07" @default.
- W2765553020 modified "2023-10-01" @default.
- W2765553020 title "Transcriptomics-driven lipidomics (TDL) identifies the microbiome-regulated targets of ileal lipid metabolism" @default.
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- W2765553020 doi "https://doi.org/10.1038/s41540-017-0033-0" @default.
- W2765553020 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5676686" @default.
- W2765553020 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29138692" @default.
- W2765553020 hasPublicationYear "2017" @default.
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