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- W2765553062 endingPage "175" @default.
- W2765553062 startingPage "168" @default.
- W2765553062 abstract "Legionella pneumophila is an intracellular pathogen and the main causative agent of Legionnaires’ disease, a potentially fatal pneumonia. The bacteria infect both mammalian cells and environmental hosts, such as amoeba. Inside host cells, the bacteria withstand the multifaceted defenses of the phagocyte and replicate within a unique membrane-bound compartment, the Legionella-containing vacuole (LCV). For establishment and maintenance of the infection, L. pneumophila secretes many proteins including effector proteins by means of different secretion systems and outer membrane vesicles. Among these are a large variety of lipolytic enzymes which possess phospholipase/lysophospholipase and/or glycerophospholipid:cholesterol acyltransferase activities. Secreted lipolytic activities may contribute to bacterial virulence, for example via modification of eukaryotic membranes, such as the LCV. In this review, we describe the secretion systems of L. pneumophila, introduce the classification of phospholipases, and summarize the state of the art on secreted L. pneumophila phospholipases. We especially highlight those enzymes secreted via the type II secretion system Lsp, via the type IVB secretion system Dot/Icm, via outer membrane vesicles, and such where the mode of secretion has not yet been defined. We also give an overview on the complexity of their activities, activation mechanisms, localization, growth-phase dependent abundance, and their role in infection." @default.
- W2765553062 created "2017-11-10" @default.
- W2765553062 creator A5002840775 @default.
- W2765553062 creator A5011470329 @default.
- W2765553062 creator A5033497702 @default.
- W2765553062 creator A5075306848 @default.
- W2765553062 date "2018-01-01" @default.
- W2765553062 modified "2023-10-01" @default.
- W2765553062 title "Secreted phospholipases of the lung pathogen Legionella pneumophila" @default.
- W2765553062 cites W1599893549 @default.
- W2765553062 cites W1727700283 @default.
- W2765553062 cites W1747289823 @default.
- W2765553062 cites W1795330227 @default.
- W2765553062 cites W1915907597 @default.
- W2765553062 cites W1932188089 @default.
- W2765553062 cites W1936705259 @default.
- W2765553062 cites W1969290128 @default.
- W2765553062 cites W1975350684 @default.
- W2765553062 cites W1978024916 @default.
- W2765553062 cites W1986311330 @default.
- W2765553062 cites W1996835975 @default.
- W2765553062 cites W1998090449 @default.
- W2765553062 cites W1999355125 @default.
- W2765553062 cites W2004745913 @default.
- W2765553062 cites W2008879639 @default.
- W2765553062 cites W2010691612 @default.
- W2765553062 cites W2011957212 @default.
- W2765553062 cites W2019615869 @default.
- W2765553062 cites W2020426458 @default.
- W2765553062 cites W2025373622 @default.
- W2765553062 cites W2028819914 @default.
- W2765553062 cites W2032108808 @default.
- W2765553062 cites W2032419237 @default.
- W2765553062 cites W2034290043 @default.
- W2765553062 cites W2040667795 @default.
- W2765553062 cites W2051946314 @default.
- W2765553062 cites W2059928376 @default.
- W2765553062 cites W2061077158 @default.
- W2765553062 cites W2061153725 @default.
- W2765553062 cites W2063908100 @default.
- W2765553062 cites W2064823286 @default.
- W2765553062 cites W2066974855 @default.
- W2765553062 cites W2068724492 @default.
- W2765553062 cites W2069513962 @default.
- W2765553062 cites W2070646288 @default.
- W2765553062 cites W2072150609 @default.
- W2765553062 cites W2074083964 @default.
- W2765553062 cites W2074613556 @default.
- W2765553062 cites W2076490464 @default.
- W2765553062 cites W2077164447 @default.
- W2765553062 cites W2077576035 @default.
- W2765553062 cites W2080563387 @default.
- W2765553062 cites W2081535038 @default.
- W2765553062 cites W2081856865 @default.
- W2765553062 cites W2086470974 @default.
- W2765553062 cites W2091056191 @default.
- W2765553062 cites W2091390126 @default.
- W2765553062 cites W2093774614 @default.
- W2765553062 cites W2096359782 @default.
- W2765553062 cites W2096915882 @default.
- W2765553062 cites W2102716378 @default.
- W2765553062 cites W2104346094 @default.
- W2765553062 cites W2105964359 @default.
- W2765553062 cites W2107685822 @default.
- W2765553062 cites W2108662926 @default.
- W2765553062 cites W2108683229 @default.
- W2765553062 cites W2110479995 @default.
- W2765553062 cites W2113174435 @default.
- W2765553062 cites W2114475032 @default.
- W2765553062 cites W2116256397 @default.
- W2765553062 cites W2116287346 @default.
- W2765553062 cites W2116612937 @default.
- W2765553062 cites W2117941971 @default.
- W2765553062 cites W2120318586 @default.
- W2765553062 cites W2121902822 @default.
- W2765553062 cites W2122144910 @default.
- W2765553062 cites W2123625327 @default.
- W2765553062 cites W2125676148 @default.
- W2765553062 cites W2125983377 @default.
- W2765553062 cites W2126839351 @default.
- W2765553062 cites W2127171502 @default.
- W2765553062 cites W2131907316 @default.
- W2765553062 cites W2134206955 @default.
- W2765553062 cites W2134466221 @default.
- W2765553062 cites W2136711242 @default.
- W2765553062 cites W2138393269 @default.
- W2765553062 cites W2140167462 @default.
- W2765553062 cites W2144216327 @default.
- W2765553062 cites W2144238311 @default.
- W2765553062 cites W2149533891 @default.
- W2765553062 cites W2152538480 @default.
- W2765553062 cites W2155795106 @default.
- W2765553062 cites W2158958374 @default.
- W2765553062 cites W2160246570 @default.
- W2765553062 cites W2160512197 @default.
- W2765553062 cites W2161502881 @default.
- W2765553062 cites W2163136327 @default.
- W2765553062 cites W2166494042 @default.