FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2765561043> ?p ?o ?g. }

• W2765561043 endingPage "512" @default.
• W2765561043 startingPage "504" @default.
• W2765561043 abstract "Summary Background Intra‐articular use of corticosteroids is commonplace in performance horses. Isoflupredone acetate ( IPA ) is one of four Food and Drug Administration approved corticosteroids for intra‐articular use in horses. The lack of published reports describing the efficacy and duration of effects of this drug warrant further study. Objectives To assess the effects of intra‐articular administration of IPA on the expression of selected anti‐ and pro‐inflammatory and structural matrix genes following intra‐articular administration to exercised Thoroughbred horses and to correlate these effects with drug concentrations. Study design Block design in vivo experiment. Methods Twelve exercised horses received either a single intra‐articular administration of 8 mg of IPA or 0.9% saline solution. Synovial fluid samples were collected prior to and up to 42 days post drug administration from the treated joints. Microarray and qRT ‐ PCR analysis were used to assess changes in expression levels of various inflammatory and structural genes post drug administration. Results On microarray analysis, 855, 23,358 and 26,411 genes had a measurable fold change (increase or decrease in expression levels) when comparing baseline samples to 24 h, baseline samples to day 7 and 24 h samples to day 7, respectively. Of the genes selected for further study by qRT ‐ PCR analysis, expression of ANXA ‐1 (lipocortin) was significantly increased and IL 23A and MMP 1 and MMP 9 significantly decreased following IPA administration. Expression levels of collagen genes were not significantly different from baseline. Main limitations Limitations include the use of a noninflammatory model as results may differ in the presence of an acute inflammatory insult and the inability to measure protein concentrations of inflammatory mediators due to limited synovial fluid sample volume. Conclusions Expression relative to baseline, for both inflammatory and matrix genes for up to 42 days post IPA administration, suggests a prolonged effect relative to detection time in both plasma and synovial fluid." @default.
• W2765561043 created "2017-11-10" @default.
• W2765561043 creator A5010029612 @default.
• W2765561043 creator A5038336989 @default.
• W2765561043 creator A5043708094 @default.
• W2765561043 creator A5078806565 @default.
• W2765561043 date "2017-11-17" @default.
• W2765561043 modified "2023-09-27" @default.
• W2765561043 title "Expression of inflammatory and structural matrix genes in synovial fluid following intra-articular administration of isoflupredone acetate to exercised horses" @default.
• W2765561043 cites W1554947160 @default.
• W2765561043 cites W1598528209 @default.
• W2765561043 cites W1680109513 @default.
• W2765561043 cites W1851683066 @default.
• W2765561043 cites W1877755747 @default.
• W2765561043 cites W1888123441 @default.
• W2765561043 cites W1951688533 @default.
• W2765561043 cites W1964783496 @default.
• W2765561043 cites W1987754032 @default.
• W2765561043 cites W1994302475 @default.
• W2765561043 cites W2000770184 @default.
• W2765561043 cites W2020541351 @default.
• W2765561043 cites W2032176743 @default.
• W2765561043 cites W2041369782 @default.
• W2765561043 cites W2047541468 @default.
• W2765561043 cites W2076853786 @default.
• W2765561043 cites W2093949724 @default.
• W2765561043 cites W2097143009 @default.
• W2765561043 cites W2110622678 @default.
• W2765561043 cites W2111110563 @default.
• W2765561043 cites W2159369930 @default.
• W2765561043 cites W2162594503 @default.
• W2765561043 cites W2169866261 @default.
• W2765561043 cites W2170599086 @default.
• W2765561043 doi "https://doi.org/10.1111/evj.12771" @default.
• W2765561043 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29044706" @default.
• W2765561043 hasPublicationYear "2017" @default.
• W2765561043 type Work @default.
• W2765561043 sameAs 2765561043 @default.
• W2765561043 citedByCount "3" @default.
• W2765561043 countsByYear W27655610432018 @default.
• W2765561043 countsByYear W27655610432022 @default.
• W2765561043 countsByYear W27655610432023 @default.
• W2765561043 crossrefType "journal-article" @default.
• W2765561043 hasAuthorship W2765561043A5010029612 @default.
• W2765561043 hasAuthorship W2765561043A5038336989 @default.
• W2765561043 hasAuthorship W2765561043A5043708094 @default.
• W2765561043 hasAuthorship W2765561043A5078806565 @default.
• W2765561043 hasConcept C104317684 @default.
• W2765561043 hasConcept C126322002 @default.
• W2765561043 hasConcept C129527566 @default.
• W2765561043 hasConcept C142724271 @default.
• W2765561043 hasConcept C150194340 @default.
• W2765561043 hasConcept C151730666 @default.
• W2765561043 hasConcept C186836561 @default.
• W2765561043 hasConcept C204787440 @default.
• W2765561043 hasConcept C2776164576 @default.
• W2765561043 hasConcept C2776268809 @default.
• W2765561043 hasConcept C2777397205 @default.
• W2765561043 hasConcept C2780035454 @default.
• W2765561043 hasConcept C2780762169 @default.
• W2765561043 hasConcept C2987276129 @default.
• W2765561043 hasConcept C55493867 @default.
• W2765561043 hasConcept C71924100 @default.
• W2765561043 hasConcept C86803240 @default.
• W2765561043 hasConcept C98274493 @default.
• W2765561043 hasConceptScore W2765561043C104317684 @default.
• W2765561043 hasConceptScore W2765561043C126322002 @default.
• W2765561043 hasConceptScore W2765561043C129527566 @default.
• W2765561043 hasConceptScore W2765561043C142724271 @default.
• W2765561043 hasConceptScore W2765561043C150194340 @default.
• W2765561043 hasConceptScore W2765561043C151730666 @default.
• W2765561043 hasConceptScore W2765561043C186836561 @default.
• W2765561043 hasConceptScore W2765561043C204787440 @default.
• W2765561043 hasConceptScore W2765561043C2776164576 @default.
• W2765561043 hasConceptScore W2765561043C2776268809 @default.
• W2765561043 hasConceptScore W2765561043C2777397205 @default.
• W2765561043 hasConceptScore W2765561043C2780035454 @default.
• W2765561043 hasConceptScore W2765561043C2780762169 @default.
• W2765561043 hasConceptScore W2765561043C2987276129 @default.
• W2765561043 hasConceptScore W2765561043C55493867 @default.
• W2765561043 hasConceptScore W2765561043C71924100 @default.
• W2765561043 hasConceptScore W2765561043C86803240 @default.
• W2765561043 hasConceptScore W2765561043C98274493 @default.
• W2765561043 hasFunder F4320306716 @default.
• W2765561043 hasIssue "4" @default.
• W2765561043 hasLocation W27655610431 @default.
• W2765561043 hasLocation W27655610432 @default.
• W2765561043 hasOpenAccess W2765561043 @default.
• W2765561043 hasPrimaryLocation W27655610431 @default.
• W2765561043 hasRelatedWork W1983994322 @default.
• W2765561043 hasRelatedWork W2053053668 @default.
• W2765561043 hasRelatedWork W2362238002 @default.
• W2765561043 hasRelatedWork W2362947020 @default.
• W2765561043 hasRelatedWork W2363156284 @default.
• W2765561043 hasRelatedWork W2363311673 @default.
• W2765561043 hasRelatedWork W2383598698 @default.
• W2765561043 hasRelatedWork W2385534162 @default.
• W2765561043 hasRelatedWork W2415025170 @default.

• next