FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2765577003> ?p ?o ?g. }

• W2765577003 abstract "Bovine purified protein derivative (bPPD) and avian purified protein derivative (aPPD) are widely used for bovine tuberculosis diagnosis. However, little is known about their qualitative and quantitative characteristics, which makes their standardisation difficult. In addition, bPPD can give false-positive tuberculosis results because of sequence homology between Mycobacterium bovis (M. bovis) and M. avium proteins. Thus, the objective of this study was to carry out a proteomic characterisation of bPPD, aPPD and an immunopurified subcomplex from bPPD called P22 in order to identify proteins contributing to cross-reactivity among these three products in tuberculosis diagnosis. Trypsin digests of bPPD, aPPD and P22 were analysed by nanoscale liquid chromatography-electrospray ionization tandem mass spectrometry. Mice were immunised with bPPD or aPPD, and their serum was tested by indirect ELISA for reactivity against these preparations as well as against P22. A total of 456 proteins were identified in bPPD, 1019 in aPPD and 118 in P22; 146 of these proteins were shared by bPPD and aPPD, and 43 were present in all three preparations. Candidate proteins that may cause cross-reactivity between bPPD and aPPD were identified based on protein abundance and antigenic propensity. Serum reactivity experiments indicated that P22 may provide greater specificity than bPPD with similar sensitivity for ELISA-type detection of antibodies against M. tuberculosis complex. The subpreparation from bPPD called P22 may be an alternative to bPPD for serodiagnosis of bovine tuberculosis, since it shares fewer proteins with aPPD than bPPD does, reducing risk of cross-reactivity with anti-M. avium antibodies." @default.
• W2765577003 created "2017-11-10" @default.
• W2765577003 creator A5011862410 @default.
• W2765577003 creator A5017116910 @default.
• W2765577003 creator A5018088412 @default.
• W2765577003 creator A5018166200 @default.
• W2765577003 creator A5023832378 @default.
• W2765577003 creator A5026581187 @default.
• W2765577003 creator A5029253643 @default.
• W2765577003 creator A5059973854 @default.
• W2765577003 creator A5061479574 @default.
• W2765577003 creator A5064412356 @default.
• W2765577003 creator A5071823092 @default.
• W2765577003 creator A5075586741 @default.
• W2765577003 creator A5082365474 @default.
• W2765577003 date "2017-11-02" @default.
• W2765577003 modified "2023-10-14" @default.
• W2765577003 title "Proteomic characterisation of bovine and avian purified protein derivatives and identification of specific antigens for serodiagnosis of bovine tuberculosis" @default.
• W2765577003 cites W1577810745 @default.
• W2765577003 cites W1658771507 @default.
• W2765577003 cites W1746756181 @default.
• W2765577003 cites W1965007186 @default.
• W2765577003 cites W1965828812 @default.
• W2765577003 cites W1986656413 @default.
• W2765577003 cites W1997504014 @default.
• W2765577003 cites W2002341659 @default.
• W2765577003 cites W2010584962 @default.
• W2765577003 cites W2014032285 @default.
• W2765577003 cites W2021337850 @default.
• W2765577003 cites W2026128471 @default.
• W2765577003 cites W2033254071 @default.
• W2765577003 cites W2035855549 @default.
• W2765577003 cites W2042648644 @default.
• W2765577003 cites W2063071751 @default.
• W2765577003 cites W2066609648 @default.
• W2765577003 cites W2073002180 @default.
• W2765577003 cites W2075941370 @default.
• W2765577003 cites W2079297676 @default.
• W2765577003 cites W2093713302 @default.
• W2765577003 cites W2094495174 @default.
• W2765577003 cites W2097485732 @default.
• W2765577003 cites W2104486115 @default.
• W2765577003 cites W2105180943 @default.
• W2765577003 cites W2106039192 @default.
• W2765577003 cites W2112050326 @default.
• W2765577003 cites W2118312563 @default.
• W2765577003 cites W2121803084 @default.
• W2765577003 cites W2124142933 @default.
• W2765577003 cites W2127148933 @default.
• W2765577003 cites W2128122313 @default.
• W2765577003 cites W2138647657 @default.
• W2765577003 cites W2139313352 @default.
• W2765577003 cites W2145782050 @default.
• W2765577003 cites W2157728001 @default.
• W2765577003 cites W2167812452 @default.
• W2765577003 cites W2289585679 @default.
• W2765577003 cites W2413335570 @default.
• W2765577003 cites W2413885787 @default.
• W2765577003 cites W2612036288 @default.
• W2765577003 cites W2945579617 @default.
• W2765577003 cites W868436125 @default.
• W2765577003 doi "https://doi.org/10.1186/s12014-017-9171-z" @default.
• W2765577003 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5669029" @default.
• W2765577003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29142508" @default.
• W2765577003 hasPublicationYear "2017" @default.
• W2765577003 type Work @default.
• W2765577003 sameAs 2765577003 @default.
• W2765577003 citedByCount "37" @default.
• W2765577003 countsByYear W27655770032018 @default.
• W2765577003 countsByYear W27655770032019 @default.
• W2765577003 countsByYear W27655770032020 @default.
• W2765577003 countsByYear W27655770032021 @default.
• W2765577003 countsByYear W27655770032022 @default.
• W2765577003 countsByYear W27655770032023 @default.
• W2765577003 crossrefType "journal-article" @default.
• W2765577003 hasAuthorship W2765577003A5011862410 @default.
• W2765577003 hasAuthorship W2765577003A5017116910 @default.
• W2765577003 hasAuthorship W2765577003A5018088412 @default.
• W2765577003 hasAuthorship W2765577003A5018166200 @default.
• W2765577003 hasAuthorship W2765577003A5023832378 @default.
• W2765577003 hasAuthorship W2765577003A5026581187 @default.
• W2765577003 hasAuthorship W2765577003A5029253643 @default.
• W2765577003 hasAuthorship W2765577003A5059973854 @default.
• W2765577003 hasAuthorship W2765577003A5061479574 @default.
• W2765577003 hasAuthorship W2765577003A5064412356 @default.
• W2765577003 hasAuthorship W2765577003A5071823092 @default.
• W2765577003 hasAuthorship W2765577003A5075586741 @default.
• W2765577003 hasAuthorship W2765577003A5082365474 @default.
• W2765577003 hasBestOaLocation W27655770031 @default.
• W2765577003 hasConcept C142724271 @default.
• W2765577003 hasConcept C147483822 @default.
• W2765577003 hasConcept C159047783 @default.
• W2765577003 hasConcept C159654299 @default.
• W2765577003 hasConcept C185592680 @default.
• W2765577003 hasConcept C203014093 @default.
• W2765577003 hasConcept C2777975735 @default.
• W2765577003 hasConcept C2779142602 @default.
• W2765577003 hasConcept C2781069245 @default.
• W2765577003 hasConcept C2910580931 @default.
• W2765577003 hasConcept C3020064264 @default.

• next