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- W2765608879 abstract "Oral mucositis is a frequent and dose-limiting side effect of radiotherapy or chemotherapy in cancer patients. We investigated the effect of basic fibroblast growth factor on radiation-induced oral mucositis in male Syrian hamsters.Oral mucositis was induced in male Syrian hamsters by a single dose of 30-Gy irradiation. Eight days after irradiation, treatment with gel containing trafermin (basic fibroblast growth factor) at 1 or 10 μg up to day-21 was initiated. Re-epithelialization was graded using a six-point scoring system for oral mucositis. Samples of hamster cheek pouches were removed for histopathologic analyses and immunohistochemistry.The oral-mucositis score decreased in a dose-dependent manner upon trafermin treatment. Trafermin (10 μg) improved oral mucositis significantly compared with vehicle. Histopathology revealed that the degree of re-epithelialization was improved by treatment with trafermin (10 μg) compared with treatment with vehicle.Administration of trafermin (10 μg) can prevent mucosal damage to hamster cheek pouches induced by irradiation." @default.
- W2765608879 created "2017-11-10" @default.
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- W2765608879 date "2017-11-06" @default.
- W2765608879 modified "2023-10-14" @default.
- W2765608879 title "Effect of basic fibroblast growth factor on radiation-induced oral mucositis in male Syrian hamsters" @default.
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- W2765608879 doi "https://doi.org/10.1080/09553002.2017.1393578" @default.
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