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• W2765613678 abstract "To examine the association of genetic polymorphisms (-308)G/A TNFα, (+250)A/G Ltα, (+36)A/G TNFR1, (+1663)A/G TNFR2 with the development of primary open angle glaucoma (POAG) among people in Central Russia.The study sample included 443 individuals, of which 252 patients with POAG and 191 individuals in the control group. Genotyping of (-308)G/A TNFα, (+250)A/G Ltα, (+36)A/G TNFR1, (+1663)A/G TNFR2 was performed using polymerase chain reaction. The distribution of alleles and genotypes of the studied DNA markers in the groups was examined by 2×2 contingency tables and χ2 with the Yates's correction for continuity and odds ratios (OR) with 95% confidence intervals (CI).Allele (-308)G TNFα (Р=0.01, OR=1.78, 95%CI 1.12-2.85) was identified as a risk factor for POAG. Homozygotes (-308) AA TNFα are at a lowest risk for development of the disease (Р=0.01, OR=0.0005). The following combination of genetic variants of cytokines were associated with a reduced risk of POAG: (+1663)A TNFR2 and (+250)G Ltα (OR=0.34).Genetic polymorphisms (-308)G/A TNFα, (+250)A/G Ltα, (+1663)A/G TNFR2 associated with the development of POAG in the population of Central Russia." @default.
• W2765613678 created "2017-11-10" @default.
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• W2765613678 date "2017-10-18" @default.
• W2765613678 modified "2023-10-01" @default.
• W2765613678 title "Genes of tumor necrosis factors and their receptors and the primary open angle glaucoma in the population of Central Russia" @default.
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• W2765613678 doi "https://doi.org/10.18240/ijo.2017.10.02" @default.
• W2765613678 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5638967" @default.
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