Matches in SemOpenAlex for { <https://semopenalex.org/work/W2765628305> ?p ?o ?g. }
- W2765628305 abstract "Abstract Oncolytic virotherapy has the disadvantage of being unsuitable for systemic delivery due to immune elimination. Liposomal encapsulation is well-recognized to reduce immune elimination and enhance the stability of drugs in the bloodstream. In the present study, the potential of liposome-encapsulated plasmid DNA of telomerase-specific oncolytic adenovirus (TelomeScan) expressing GFP (Lipo-pTS) as an oncolytic adenoviral agent suitable for systemic delivery was investigated. Lipo-pTS, which has a diameter of 40–50 nm, showed potent antitumor effects on HCT116 colon carcinoma cells in vitro and in vivo . Tumor selectivity of Lipo-pTS was independent of coxsackie and adenovirus receptor (CAR). Importantly, Lipo-pTS reduced production of adenovirus-neutralizing antibodies (AdNAbs) after intravenous administration into immune-competent mice compared to TelomeScan, and even in the presence of AdNAbs, Lipo-pTS maintained strong cytotoxicity. In conclusion, Lipo-pTS has the potential to become an oncolytic adenoviral agent suitable for systemic delivery with the characteristics of CAR-independent antitumor activity and a stealth effect on the immune system." @default.
- W2765628305 created "2017-11-10" @default.
- W2765628305 creator A5014444677 @default.
- W2765628305 creator A5015421086 @default.
- W2765628305 creator A5017489626 @default.
- W2765628305 creator A5019953032 @default.
- W2765628305 creator A5020188029 @default.
- W2765628305 creator A5033329390 @default.
- W2765628305 creator A5034496276 @default.
- W2765628305 creator A5046061642 @default.
- W2765628305 creator A5046480520 @default.
- W2765628305 creator A5049100460 @default.
- W2765628305 creator A5068717107 @default.
- W2765628305 date "2017-10-26" @default.
- W2765628305 modified "2023-09-25" @default.
- W2765628305 title "Liposome-encapsulated plasmid DNA of telomerase-specific oncolytic adenovirus with stealth effect on the immune system" @default.
- W2765628305 cites W1585705786 @default.
- W2765628305 cites W1965918908 @default.
- W2765628305 cites W1968128233 @default.
- W2765628305 cites W1975088956 @default.
- W2765628305 cites W1976041621 @default.
- W2765628305 cites W1982974605 @default.
- W2765628305 cites W1986848545 @default.
- W2765628305 cites W1986854902 @default.
- W2765628305 cites W1989230986 @default.
- W2765628305 cites W1990852576 @default.
- W2765628305 cites W2010731545 @default.
- W2765628305 cites W2011476580 @default.
- W2765628305 cites W2013765163 @default.
- W2765628305 cites W2022386076 @default.
- W2765628305 cites W2023966374 @default.
- W2765628305 cites W2039084800 @default.
- W2765628305 cites W2050987476 @default.
- W2765628305 cites W2061480909 @default.
- W2765628305 cites W2064140172 @default.
- W2765628305 cites W2076761426 @default.
- W2765628305 cites W2079647238 @default.
- W2765628305 cites W2088446904 @default.
- W2765628305 cites W2103747165 @default.
- W2765628305 cites W2113506065 @default.
- W2765628305 cites W2128023051 @default.
- W2765628305 cites W2141196290 @default.
- W2765628305 cites W2144584725 @default.
- W2765628305 cites W2155457105 @default.
- W2765628305 cites W2162044353 @default.
- W2765628305 cites W2171083652 @default.
- W2765628305 cites W2319745661 @default.
- W2765628305 cites W2416144252 @default.
- W2765628305 cites W2473956396 @default.
- W2765628305 cites W3191062208 @default.
- W2765628305 cites W3193420004 @default.
- W2765628305 cites W339838209 @default.
- W2765628305 doi "https://doi.org/10.1038/s41598-017-14717-x" @default.
- W2765628305 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5658411" @default.
- W2765628305 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29074882" @default.
- W2765628305 hasPublicationYear "2017" @default.
- W2765628305 type Work @default.
- W2765628305 sameAs 2765628305 @default.
- W2765628305 citedByCount "19" @default.
- W2765628305 countsByYear W27656283052018 @default.
- W2765628305 countsByYear W27656283052019 @default.
- W2765628305 countsByYear W27656283052020 @default.
- W2765628305 countsByYear W27656283052021 @default.
- W2765628305 countsByYear W27656283052022 @default.
- W2765628305 countsByYear W27656283052023 @default.
- W2765628305 crossrefType "journal-article" @default.
- W2765628305 hasAuthorship W2765628305A5014444677 @default.
- W2765628305 hasAuthorship W2765628305A5015421086 @default.
- W2765628305 hasAuthorship W2765628305A5017489626 @default.
- W2765628305 hasAuthorship W2765628305A5019953032 @default.
- W2765628305 hasAuthorship W2765628305A5020188029 @default.
- W2765628305 hasAuthorship W2765628305A5033329390 @default.
- W2765628305 hasAuthorship W2765628305A5034496276 @default.
- W2765628305 hasAuthorship W2765628305A5046061642 @default.
- W2765628305 hasAuthorship W2765628305A5046480520 @default.
- W2765628305 hasAuthorship W2765628305A5049100460 @default.
- W2765628305 hasAuthorship W2765628305A5068717107 @default.
- W2765628305 hasBestOaLocation W27656283051 @default.
- W2765628305 hasConcept C104317684 @default.
- W2765628305 hasConcept C109316439 @default.
- W2765628305 hasConcept C125593758 @default.
- W2765628305 hasConcept C150903083 @default.
- W2765628305 hasConcept C159047783 @default.
- W2765628305 hasConcept C202751555 @default.
- W2765628305 hasConcept C203014093 @default.
- W2765628305 hasConcept C207001950 @default.
- W2765628305 hasConcept C2522874641 @default.
- W2765628305 hasConcept C25938499 @default.
- W2765628305 hasConcept C2777283488 @default.
- W2765628305 hasConcept C49744831 @default.
- W2765628305 hasConcept C502942594 @default.
- W2765628305 hasConcept C55493867 @default.
- W2765628305 hasConcept C71924100 @default.
- W2765628305 hasConcept C82210918 @default.
- W2765628305 hasConcept C86803240 @default.
- W2765628305 hasConcept C8891405 @default.
- W2765628305 hasConcept C94581717 @default.
- W2765628305 hasConceptScore W2765628305C104317684 @default.
- W2765628305 hasConceptScore W2765628305C109316439 @default.
- W2765628305 hasConceptScore W2765628305C125593758 @default.