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- W2765641908 abstract "Abstract RNA editing introduces single nucleotide changes to RNA, thus potentially diversifying gene expression. Recent studies have reported significant changes in RNA editing profiles in disease and development. The functional consequences of these widespread alterations remain elusive because of the unknown function of most RNA editing sites. Here, we carry out a comprehensive analysis of A-to-I editomes in human populations. Surprisingly, we observe highly similar editing profiles across populations despite striking differences in the expression levels of ADAR genes. Striving to explain this discrepancy, we uncover a functional mechanism of A-to-I editing in regulating mRNA abundance. We show that A-to-I editing stabilizes RNA secondary structures and reduces the accessibility of AGO2-miRNA to target sites in mRNAs. The editing-dependent stabilization of mRNAs in turn alters the observed editing levels in the stable RNA repertoire. Our study provides valuable insights into the functional impact of RNA editing in human cells." @default.
- W2765641908 created "2017-11-10" @default.
- W2765641908 creator A5011475638 @default.
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- W2765641908 creator A5062043914 @default.
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- W2765641908 date "2017-11-02" @default.
- W2765641908 modified "2023-10-10" @default.
- W2765641908 title "Structure-mediated modulation of mRNA abundance by A-to-I editing" @default.
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- W2765641908 doi "https://doi.org/10.1038/s41467-017-01459-7" @default.
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