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• W2765642278 endingPage "70" @default.
• W2765642278 startingPage "62" @default.
• W2765642278 abstract "Planar cell polarity (PCP) refers to the capacity of a tissue, typically, but not exclusively, an epithelium, to transmit directional information across the tissue plane such that its cellular constituents can differentiate, divide or move in a coordinated manner and along a common axis, generally orthogonal to the apical-basal axis. PCP relies on a core module of highly conserved proteins originally identified in Drosophila which can act intra- and extracellularly. In this review, we focus on the vertebrate ortholog of one of these core PCP components, namely the Vangl2 protein. After a brief historical perspective, we discuss novel cellular settings for which a cellular Vangl2 requirement has been recently documented, with a particular emphasis on adult tissues that rely on Vangl2 for the maintenance of their regenerative capacity or their physiological functions. Finally we compile the most recent data about Vangl2 interacting proteins." @default.
• W2765642278 created "2017-11-10" @default.
• W2765642278 creator A5007070901 @default.
• W2765642278 creator A5072213737 @default.
• W2765642278 creator A5083822022 @default.
• W2765642278 date "2018-09-01" @default.
• W2765642278 modified "2023-10-15" @default.
• W2765642278 title "The planar cell polarity Vangl2 protein: From genetics to cellular and molecular functions" @default.
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• W2765642278 doi "https://doi.org/10.1016/j.semcdb.2017.10.030" @default.

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