FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2765646903> ?p ?o ?g. }

• W2765646903 endingPage "398" @default.
• W2765646903 startingPage "375" @default.
• W2765646903 abstract "Significance: Diabetic cardiomyopathy (DCM) is a frequent complication occurring even in well-controlled asymptomatic diabetic patients, and it may advance to heart failure (HF). Recent Advances: The diabetic heart is characterized by a state of metabolic rigidity involving enhanced rates of fatty acid uptake and mitochondrial oxidation as the predominant energy source, and it exhibits mitochondrial electron transport chain defects. These alterations promote redox state changes evidenced by a decreased NAD+/NADH ratio associated with an increase in acetyl-CoA/CoA ratio. NAD+ is a co-substrate for deacetylases, sirtuins, and a critical molecule in metabolism and redox signaling; whereas acetyl-CoA promotes protein lysine acetylation, affecting mitochondrial integrity and causing epigenetic changes. Critical Issues: DCM lacks specific therapies with treatment only in later disease stages using standard, palliative HF interventions. Traditional therapy targeting neurohormonal signaling and hemodynamics failed to improve mortality rates. Though mitochondrial redox state changes occur in the heart with obesity and diabetes, how the mitochondrial NAD+/NADH redox couple connects the remodeled energy metabolism with mitochondrial and cytosolic antioxidant defense and nuclear epigenetic changes remains to be determined. Mitochondrial therapies targeting the mitochondrial NAD+/NADH redox ratio may alleviate cardiac dysfunction. Future Directions: Specific therapies must be supported by an optimal understanding of changes in mitochondrial redox state and how it influences other cellular compartments; this field has begun to surface as a therapeutic target for the diabetic heart. We propose an approach based on an alternate mitochondrial electron transport that normalizes the mitochondrial redox state and improves cardiac function in diabetes." @default.
• W2765646903 created "2017-11-10" @default.
• W2765646903 creator A5009119759 @default.
• W2765646903 creator A5015477824 @default.
• W2765646903 creator A5044162050 @default.
• W2765646903 creator A5056221856 @default.
• W2765646903 date "2019-01-20" @default.
• W2765646903 modified "2023-10-17" @default.
• W2765646903 title "Mitochondrial NAD⁺/NADH Redox State and Diabetic Cardiomyopathy" @default.
• W2765646903 cites W1529592271 @default.
• W2765646903 cites W1595491423 @default.
• W2765646903 cites W1752066541 @default.
• W2765646903 cites W1826460582 @default.
• W2765646903 cites W1842335527 @default.
• W2765646903 cites W1848231049 @default.
• W2765646903 cites W1938241710 @default.
• W2765646903 cites W1959721425 @default.
• W2765646903 cites W1964059126 @default.
• W2765646903 cites W1964430604 @default.
• W2765646903 cites W1964564264 @default.
• W2765646903 cites W1965935659 @default.
• W2765646903 cites W1966985989 @default.
• W2765646903 cites W1968890500 @default.
• W2765646903 cites W1970060454 @default.
• W2765646903 cites W1971082641 @default.
• W2765646903 cites W1972670427 @default.
• W2765646903 cites W1974939683 @default.
• W2765646903 cites W1975013703 @default.
• W2765646903 cites W1975557286 @default.
• W2765646903 cites W1979000436 @default.
• W2765646903 cites W1980232211 @default.
• W2765646903 cites W1981708660 @default.
• W2765646903 cites W1985977889 @default.
• W2765646903 cites W1986276307 @default.
• W2765646903 cites W1987090578 @default.
• W2765646903 cites W1991594467 @default.
• W2765646903 cites W1993987541 @default.
• W2765646903 cites W1994044009 @default.
• W2765646903 cites W1994574239 @default.
• W2765646903 cites W1996376927 @default.
• W2765646903 cites W1999697076 @default.
• W2765646903 cites W2001466001 @default.
• W2765646903 cites W2002393930 @default.
• W2765646903 cites W2010169277 @default.
• W2765646903 cites W2012589717 @default.
• W2765646903 cites W2012740748 @default.
• W2765646903 cites W2012898950 @default.
• W2765646903 cites W2013146358 @default.
• W2765646903 cites W2013454579 @default.
• W2765646903 cites W2013841882 @default.
• W2765646903 cites W2014671368 @default.
• W2765646903 cites W2015590649 @default.
• W2765646903 cites W2017225012 @default.
• W2765646903 cites W2018138013 @default.
• W2765646903 cites W2018289835 @default.
• W2765646903 cites W2020304127 @default.
• W2765646903 cites W2021645116 @default.
• W2765646903 cites W2022267544 @default.
• W2765646903 cites W2022516880 @default.
• W2765646903 cites W2022664710 @default.
• W2765646903 cites W2023657018 @default.
• W2765646903 cites W2026525843 @default.
• W2765646903 cites W2026859489 @default.
• W2765646903 cites W2029803289 @default.
• W2765646903 cites W2030272109 @default.
• W2765646903 cites W2030405841 @default.
• W2765646903 cites W2030760870 @default.
• W2765646903 cites W2031022790 @default.
• W2765646903 cites W2031363155 @default.
• W2765646903 cites W2033007699 @default.
• W2765646903 cites W2036152956 @default.
• W2765646903 cites W2036622571 @default.
• W2765646903 cites W2037229939 @default.
• W2765646903 cites W2037877475 @default.
• W2765646903 cites W2038317187 @default.
• W2765646903 cites W2038468721 @default.
• W2765646903 cites W2040625305 @default.
• W2765646903 cites W2040736163 @default.
• W2765646903 cites W2041128667 @default.
• W2765646903 cites W2042348197 @default.
• W2765646903 cites W2042685228 @default.
• W2765646903 cites W2045051842 @default.
• W2765646903 cites W2046938310 @default.
• W2765646903 cites W2047265080 @default.
• W2765646903 cites W2048672285 @default.
• W2765646903 cites W2049266192 @default.
• W2765646903 cites W2050425575 @default.
• W2765646903 cites W2052751736 @default.
• W2765646903 cites W2058768220 @default.
• W2765646903 cites W2061077538 @default.
• W2765646903 cites W2061914106 @default.
• W2765646903 cites W2064437293 @default.
• W2765646903 cites W2064966129 @default.
• W2765646903 cites W2071228656 @default.
• W2765646903 cites W2071789967 @default.
• W2765646903 cites W2073848428 @default.
• W2765646903 cites W2074485395 @default.
• W2765646903 cites W2075747312 @default.

• next