FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2765648311> ?p ?o ?g. }

• W2765648311 endingPage "13" @default.
• W2765648311 startingPage "8" @default.
• W2765648311 abstract "Injuries to the central nervous system can affect the blood-brain barrier (BBB), including disruption and influencing peptide transport across the BBB. Pituitary adenylate cyclase-activating polypeptide 38 (PACAP38) is a potent neurotrophic and neuroprotective peptide currently being investigated for its therapeutic role following injury to the central nervous system and can cross the BBB in a saturable manner. The goal of the current study was to investigate for the first time PACAP38 uptake by the brain following traumatic brain injury (TBI). Using radioactively labeled PACAP38, we measured the levels of PACAP38 present in the injured, ipsilateral cortex in Sham-treated mice compared to mice receiving a controlled cortical impact (CCI), a model of TBI. Experiments were conducted at 6 different time points (from 2 h up to 4 weeks) following CCI to determine temporal changes in PACAP38 transport. PACAP38 uptake was increased at 2 and 72 h post-CCI compared to Sham. We did not detect changes in PACAP38 uptake in the contralateral cortex and cerebellum between Sham and CCI-treatment. The rate of PACAP38 transport into the ipsilateral cortex following CCI was increased 3.6-fold 72 h after compared to 2 h post-CCI. In addition, the rate of transport into the cerebellum was greater than that of the cortices. The data presented here shows PACAP38 transport is temporally altered following CCI-treatment and PACAP38 uptake is greater in the cerebellum compared to the cortices." @default.
• W2765648311 created "2017-11-10" @default.
• W2765648311 creator A5012502467 @default.
• W2765648311 creator A5054959155 @default.
• W2765648311 creator A5090619468 @default.
• W2765648311 date "2018-01-01" @default.
• W2765648311 modified "2023-10-16" @default.
• W2765648311 title "Effect of controlled cortical impact on the passage of pituitary adenylate cyclase activating polypeptide (PACAP) across the blood-brain barrier" @default.
• W2765648311 cites W1194913466 @default.
• W2765648311 cites W1975882246 @default.
• W2765648311 cites W1976490782 @default.
• W2765648311 cites W1981423842 @default.
• W2765648311 cites W1996836354 @default.
• W2765648311 cites W1998391893 @default.
• W2765648311 cites W2011378958 @default.
• W2765648311 cites W2042445968 @default.
• W2765648311 cites W2044033043 @default.
• W2765648311 cites W2048449932 @default.
• W2765648311 cites W2063024845 @default.
• W2765648311 cites W2067624621 @default.
• W2765648311 cites W2071425128 @default.
• W2765648311 cites W2082909705 @default.
• W2765648311 cites W2092078486 @default.
• W2765648311 cites W2094715296 @default.
• W2765648311 cites W2150857468 @default.
• W2765648311 cites W2163152572 @default.
• W2765648311 cites W2235097232 @default.
• W2765648311 cites W2286831469 @default.
• W2765648311 cites W2488581011 @default.
• W2765648311 doi "https://doi.org/10.1016/j.peptides.2017.10.013" @default.
• W2765648311 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5756113" @default.
• W2765648311 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29107653" @default.
• W2765648311 hasPublicationYear "2018" @default.
• W2765648311 type Work @default.
• W2765648311 sameAs 2765648311 @default.
• W2765648311 citedByCount "5" @default.
• W2765648311 countsByYear W27656483112019 @default.
• W2765648311 countsByYear W27656483112020 @default.
• W2765648311 countsByYear W27656483112021 @default.
• W2765648311 countsByYear W27656483112022 @default.
• W2765648311 crossrefType "journal-article" @default.
• W2765648311 hasAuthorship W2765648311A5012502467 @default.
• W2765648311 hasAuthorship W2765648311A5054959155 @default.
• W2765648311 hasAuthorship W2765648311A5090619468 @default.
• W2765648311 hasBestOaLocation W27656483111 @default.
• W2765648311 hasConcept C118552586 @default.
• W2765648311 hasConcept C126322002 @default.
• W2765648311 hasConcept C134018914 @default.
• W2765648311 hasConcept C169760540 @default.
• W2765648311 hasConcept C170493617 @default.
• W2765648311 hasConcept C180526460 @default.
• W2765648311 hasConcept C185592680 @default.
• W2765648311 hasConcept C24998067 @default.
• W2765648311 hasConcept C25498285 @default.
• W2765648311 hasConcept C2777348757 @default.
• W2765648311 hasConcept C2779652256 @default.
• W2765648311 hasConcept C2780069284 @default.
• W2765648311 hasConcept C2781017439 @default.
• W2765648311 hasConcept C2781041448 @default.
• W2765648311 hasConcept C42219234 @default.
• W2765648311 hasConcept C529278444 @default.
• W2765648311 hasConcept C71924100 @default.
• W2765648311 hasConcept C86803240 @default.
• W2765648311 hasConcept C92020748 @default.
• W2765648311 hasConceptScore W2765648311C118552586 @default.
• W2765648311 hasConceptScore W2765648311C126322002 @default.
• W2765648311 hasConceptScore W2765648311C134018914 @default.
• W2765648311 hasConceptScore W2765648311C169760540 @default.
• W2765648311 hasConceptScore W2765648311C170493617 @default.
• W2765648311 hasConceptScore W2765648311C180526460 @default.
• W2765648311 hasConceptScore W2765648311C185592680 @default.
• W2765648311 hasConceptScore W2765648311C24998067 @default.
• W2765648311 hasConceptScore W2765648311C25498285 @default.
• W2765648311 hasConceptScore W2765648311C2777348757 @default.
• W2765648311 hasConceptScore W2765648311C2779652256 @default.
• W2765648311 hasConceptScore W2765648311C2780069284 @default.
• W2765648311 hasConceptScore W2765648311C2781017439 @default.
• W2765648311 hasConceptScore W2765648311C2781041448 @default.
• W2765648311 hasConceptScore W2765648311C42219234 @default.
• W2765648311 hasConceptScore W2765648311C529278444 @default.
• W2765648311 hasConceptScore W2765648311C71924100 @default.
• W2765648311 hasConceptScore W2765648311C86803240 @default.
• W2765648311 hasConceptScore W2765648311C92020748 @default.
• W2765648311 hasLocation W27656483111 @default.
• W2765648311 hasLocation W27656483112 @default.
• W2765648311 hasLocation W27656483113 @default.
• W2765648311 hasOpenAccess W2765648311 @default.
• W2765648311 hasPrimaryLocation W27656483111 @default.
• W2765648311 hasRelatedWork W1978419663 @default.
• W2765648311 hasRelatedWork W2019744095 @default.
• W2765648311 hasRelatedWork W2025626785 @default.
• W2765648311 hasRelatedWork W2027266387 @default.
• W2765648311 hasRelatedWork W2029369136 @default.
• W2765648311 hasRelatedWork W2056306087 @default.
• W2765648311 hasRelatedWork W2077205476 @default.
• W2765648311 hasRelatedWork W2155585839 @default.
• W2765648311 hasRelatedWork W2159228864 @default.
• W2765648311 hasRelatedWork W2398181117 @default.

• next