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• W2765649845 abstract "BackgroundImpaired consciousness has been associated with impaired cortical signal propagation after transcranial magnetic stimulation (TMS). We hypothesised that the reduced current propagation under propofol-induced unresponsiveness is associated with changes in both feedforward and feedback connectivity across the cortical hierarchy.MethodsEight subjects underwent left occipital TMS coupled with high-density EEG recordings during wakefulness and propofol-induced unconsciousness. Spectral analysis was applied to responses recorded from sensors overlying six hierarchical cortical sources involved in visual processing. Dynamic causal modelling (DCM) of induced time–frequency responses and evoked response potentials were used to investigate propofol's effects on connectivity between regions.ResultsSensor space analysis demonstrated that propofol reduced both induced and evoked power after TMS in occipital, parietal, and frontal electrodes. Bayesian model selection supported a DCM with hierarchical feedforward and feedback connections. DCM of induced EEG responses revealed that the primary effect of propofol was impaired feedforward responses in cross-frequency theta/alpha–gamma coupling and within frequency theta coupling (F contrast, family-wise error corrected P<0.05). An exploratory analysis (thresholded at uncorrected P<0.001) also suggested that propofol impaired feedforward and feedback beta band coupling. Post hoc analyses showed impairments in all feedforward connections and one feedback connection from parietal to occipital cortex. DCM of the evoked response potential showed impaired feedforward connectivity between left-sided occipital and parietal cortex (T contrast P=0.004, Bonferroni corrected).ConclusionsPropofol-induced loss of consciousness is associated with impaired hierarchical feedforward connectivity assessed by EEG after occipital TMS." @default.
• W2765649845 created "2017-11-10" @default.
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• W2765649845 date "2018-11-01" @default.
• W2765649845 modified "2023-10-03" @default.
• W2765649845 title "Propofol-induced unresponsiveness is associated with impaired feedforward connectivity in cortical hierarchy" @default.
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• W2765649845 cites W1978389345 @default.
• W2765649845 cites W1978476682 @default.
• W2765649845 cites W1979155542 @default.
• W2765649845 cites W1983192672 @default.
• W2765649845 cites W1986936461 @default.
• W2765649845 cites W1995637220 @default.
• W2765649845 cites W2003454395 @default.
• W2765649845 cites W2007241321 @default.
• W2765649845 cites W2013176407 @default.
• W2765649845 cites W2017347948 @default.
• W2765649845 cites W2022169516 @default.
• W2765649845 cites W2022438346 @default.
• W2765649845 cites W2026234315 @default.
• W2765649845 cites W2027191389 @default.
• W2765649845 cites W2028985479 @default.
• W2765649845 cites W2032358302 @default.
• W2765649845 cites W2036682006 @default.
• W2765649845 cites W2038546371 @default.
• W2765649845 cites W2040327687 @default.
• W2765649845 cites W2041625311 @default.
• W2765649845 cites W2045823870 @default.
• W2765649845 cites W2051850587 @default.
• W2765649845 cites W2053773581 @default.
• W2765649845 cites W2074671627 @default.
• W2765649845 cites W2074766820 @default.
• W2765649845 cites W2075117230 @default.
• W2765649845 cites W2076345183 @default.
• W2765649845 cites W2079028648 @default.
• W2765649845 cites W2087017542 @default.
• W2765649845 cites W2094508169 @default.
• W2765649845 cites W2095487159 @default.
• W2765649845 cites W2096629297 @default.
• W2765649845 cites W2097954642 @default.
• W2765649845 cites W2098580305 @default.
• W2765649845 cites W2102204212 @default.
• W2765649845 cites W2112639978 @default.
• W2765649845 cites W2114900706 @default.
• W2765649845 cites W2116238171 @default.
• W2765649845 cites W2116360511 @default.
• W2765649845 cites W2117731089 @default.
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• W2765649845 cites W2121409298 @default.
• W2765649845 cites W2121604350 @default.
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• W2765649845 cites W2126155630 @default.
• W2765649845 cites W2133352409 @default.
• W2765649845 cites W2133854825 @default.
• W2765649845 cites W2135390742 @default.
• W2765649845 cites W2138635047 @default.
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• W2765649845 cites W2212776331 @default.
• W2765649845 cites W2227520796 @default.
• W2765649845 cites W2256863106 @default.
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• W2765649845 cites W2744610723 @default.
• W2765649845 cites W4211177544 @default.
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• W2765649845 doi "https://doi.org/10.1016/j.bja.2018.07.006" @default.
• W2765649845 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6208295" @default.
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