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- W2765654265 abstract "The association between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and colorectal cancer (CRC) susceptibility has been researched in numerous studies. However, the results of these studies were controversial. Therefore, the objective of this meta-analysis was to offer a more convincible conclusion about such association with more included studies. Eligible studies published till May 1, 2017 were searched from PubMed, Embase, Web of Science, and CNKI database about such association. Pooled odds ratios (ORs) together with 95% confidence intervals (CIs) were calculated to evaluate such association. And the Begg’s funnel plot and Egger’s test were applied to assess the publication bias. This meta-analysis contained 37049 cases and 52444 controls from 87 publications with 91 eligible case–control studies. Because of lack of data for a particular genotype in several studies, all the included studies were analysed barely in the dominant model. Originally, there was no association between MTHFR C677T polymorphism and CRC susceptibility (OR =0.99, 95% CI =0.94–1.05). After excluding 13 studies according to their heterogeneity and publication bias, rs1801133 polymorphism was found to reduce the risks of CRC significantly (OR =0.96, 95% CI =0.94–0.99). In the subgroup analysis of ethnicity, there was a significant association in Asians (OR =0.94, 95% CI =0.89–1.00). Furthermore, when stratified by the source of controls and genotyping methods, the positive results were observed in population-based control group (OR =0.97, 95% CI =0.93–1.00) and PCR-restriction fragment length polymorphism (PCR-RFLP) method (OR =0.95, 95% CI =0.91–0.99. The results of the meta-analysis suggested that MTHFR C677T polymorphism was associated with CRC susceptibility, especially in Asian population." @default.
- W2765654265 created "2017-11-10" @default.
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- W2765654265 date "2017-12-07" @default.
- W2765654265 modified "2023-10-02" @default.
- W2765654265 title "Methylenetetrahydrofolate reductase C677T polymorphism and colorectal cancer susceptibility: a meta-analysis" @default.
- W2765654265 cites W1547003604 @default.
- W2765654265 cites W1572305422 @default.
- W2765654265 cites W1861722028 @default.
- W2765654265 cites W1895706190 @default.
- W2765654265 cites W1925208328 @default.
- W2765654265 cites W1954873734 @default.
- W2765654265 cites W1969376022 @default.
- W2765654265 cites W1975564825 @default.
- W2765654265 cites W1977879763 @default.
- W2765654265 cites W1981217021 @default.
- W2765654265 cites W1984541678 @default.
- W2765654265 cites W1986558627 @default.
- W2765654265 cites W1986561336 @default.
- W2765654265 cites W1988434324 @default.
- W2765654265 cites W1994601461 @default.
- W2765654265 cites W2000712563 @default.
- W2765654265 cites W2008767573 @default.
- W2765654265 cites W2010868528 @default.
- W2765654265 cites W2011905673 @default.
- W2765654265 cites W2012983926 @default.
- W2765654265 cites W2013526328 @default.
- W2765654265 cites W2018683939 @default.
- W2765654265 cites W2022251295 @default.
- W2765654265 cites W2023110564 @default.
- W2765654265 cites W2025231171 @default.
- W2765654265 cites W2025529949 @default.
- W2765654265 cites W2029544232 @default.
- W2765654265 cites W2029776920 @default.
- W2765654265 cites W2030356384 @default.
- W2765654265 cites W2030515524 @default.
- W2765654265 cites W2031262735 @default.
- W2765654265 cites W2031875568 @default.
- W2765654265 cites W2046062863 @default.
- W2765654265 cites W2048436571 @default.
- W2765654265 cites W2050917119 @default.
- W2765654265 cites W2053043700 @default.
- W2765654265 cites W2059468777 @default.
- W2765654265 cites W2059628849 @default.
- W2765654265 cites W2063297627 @default.
- W2765654265 cites W2067336969 @default.
- W2765654265 cites W2068011516 @default.
- W2765654265 cites W2071090045 @default.
- W2765654265 cites W2074751305 @default.
- W2765654265 cites W2075762459 @default.
- W2765654265 cites W2075800819 @default.
- W2765654265 cites W2078096478 @default.
- W2765654265 cites W2078160307 @default.
- W2765654265 cites W2081061103 @default.
- W2765654265 cites W2082472491 @default.
- W2765654265 cites W2084494571 @default.
- W2765654265 cites W2086155534 @default.
- W2765654265 cites W2093336903 @default.
- W2765654265 cites W2095692554 @default.
- W2765654265 cites W2096430092 @default.
- W2765654265 cites W2098388063 @default.
- W2765654265 cites W2099671242 @default.
- W2765654265 cites W2100185175 @default.
- W2765654265 cites W2100443476 @default.
- W2765654265 cites W2100602435 @default.
- W2765654265 cites W2101546034 @default.
- W2765654265 cites W2103428677 @default.
- W2765654265 cites W2105041333 @default.
- W2765654265 cites W2106505043 @default.
- W2765654265 cites W2106681265 @default.
- W2765654265 cites W2107362480 @default.
- W2765654265 cites W2112170654 @default.
- W2765654265 cites W2113738649 @default.
- W2765654265 cites W2117144296 @default.
- W2765654265 cites W2118668725 @default.
- W2765654265 cites W2126969815 @default.
- W2765654265 cites W2131569634 @default.
- W2765654265 cites W2135243938 @default.
- W2765654265 cites W2136721576 @default.
- W2765654265 cites W2140587505 @default.
- W2765654265 cites W2144600312 @default.
- W2765654265 cites W2145134975 @default.
- W2765654265 cites W2145266104 @default.
- W2765654265 cites W2148461273 @default.
- W2765654265 cites W2149502619 @default.
- W2765654265 cites W2151972971 @default.
- W2765654265 cites W2153572829 @default.
- W2765654265 cites W2157434862 @default.
- W2765654265 cites W2159874711 @default.
- W2765654265 cites W2161069925 @default.
- W2765654265 cites W2161129360 @default.