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- W2765660265 abstract "Trichoderma reesei represents one of the most prolific producers of homologous and heterologous proteins. Discovery of the photoreceptor ENV1 as a regulator of cellulase gene expression initiated analysis of light response pathways and their physiological relevance for T. reesei. The function of ENV1 in regulation of plant cell wall degrading enzymes is conserved in Neurospora crassa. ENV1 emerged as a central checkpoint for integration of nutrient sensing, light response and development. This photoreceptor exerts its function by influencing transcript abundance and feedback cycles of the alpha subunits of the heterotrimeric G-protein pathway and impacts regulation of the beta and gamma subunits via mutual regulation with the phosducin PhLP1. The output of regulation by ENV1 is in part mediated by the cAMP pathway and likely aimed at cellulose recognition. Lack of ENV1 causes deregulation of the pheromone system and female sterility in light. A regulatory interconnection with VEL1 and influence on other regulators of secondary metabolism like YPR2 as well as polyketide synthase encoding genes indicates a function in secondary metabolism. The function of ENV1 in integrating light response with signaling of osmotic and oxidative stress is evolutionary conserved in Hypocreales and distinct from other sordariomycetes including N. crassa." @default.
- W2765660265 created "2017-11-10" @default.
- W2765660265 creator A5003978738 @default.
- W2765660265 date "2018-06-01" @default.
- W2765660265 modified "2023-10-18" @default.
- W2765660265 title "Light, stress, sex and carbon – The photoreceptor ENVOY as a central checkpoint in the physiology of Trichoderma reesei" @default.
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- W2765660265 doi "https://doi.org/10.1016/j.funbio.2017.10.007" @default.
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