FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2765667906> ?p ?o ?g. }

• W2765667906 endingPage "2333" @default.
• W2765667906 startingPage "2324" @default.
• W2765667906 abstract "Diacylglycerol kinases (DGKs) regulate the balance between diacylglycerol (DAG) and phosphatidic acid. DGKζ is highly abundant in skeletal muscle and induces fiber hypertrophy. We hypothesized that DGKζ influences functional and metabolic adaptations in skeletal muscle and whole-body fuel utilization. DAG content was increased in skeletal muscle and adipose tissue, but unaltered in liver of DGKζ KO mice. Linear growth, body weight, fat mass, and lean mass were reduced in DGKζ KO versus wild-type mice. Conversely, male DGKζ KO and wild-type mice displayed a similar robust increase in plantaris weight after functional overload, suggesting that DGKζ is dispensable for muscle hypertrophy. Although glucose tolerance was similar, insulin levels were reduced in high-fat diet (HFD)-fed DGKζ KO versus wild-type mice. Submaximal insulin-stimulated glucose transport and p-Akt Ser473 were increased, suggesting enhanced skeletal muscle insulin sensitivity. Energy homeostasis was altered in DGKζ KO mice, as evidenced by an elevated respiratory exchange ratio, independent of altered physical activity or food intake. In conclusion, DGKζ deficiency increases tissue DAG content and leads to modest growth retardation, reduced adiposity, and protection against insulin resistance. DGKζ plays a role in the control of growth and metabolic processes, further highlighting specialized functions of DGK isoforms in type 2 diabetes pathophysiology." @default.
• W2765667906 created "2017-11-10" @default.
• W2765667906 creator A5000008605 @default.
• W2765667906 creator A5002484573 @default.
• W2765667906 creator A5019780697 @default.
• W2765667906 creator A5027492511 @default.
• W2765667906 creator A5034299091 @default.
• W2765667906 creator A5045077954 @default.
• W2765667906 creator A5059519671 @default.
• W2765667906 creator A5063215068 @default.
• W2765667906 creator A5063387242 @default.
• W2765667906 date "2017-12-01" @default.
• W2765667906 modified "2023-10-04" @default.
• W2765667906 title "DGKζ deficiency protects against peripheral insulin resistance and improves energy metabolism" @default.
• W2765667906 cites W1593328663 @default.
• W2765667906 cites W1933897045 @default.
• W2765667906 cites W1965291256 @default.
• W2765667906 cites W1976826120 @default.
• W2765667906 cites W1979721410 @default.
• W2765667906 cites W1982858761 @default.
• W2765667906 cites W1983327197 @default.
• W2765667906 cites W1990038678 @default.
• W2765667906 cites W1995763262 @default.
• W2765667906 cites W2000932018 @default.
• W2765667906 cites W2002440150 @default.
• W2765667906 cites W2011277467 @default.
• W2765667906 cites W2012898950 @default.
• W2765667906 cites W2013706577 @default.
• W2765667906 cites W2017472601 @default.
• W2765667906 cites W2023060633 @default.
• W2765667906 cites W2032345647 @default.
• W2765667906 cites W2035282582 @default.
• W2765667906 cites W2036841744 @default.
• W2765667906 cites W2038011873 @default.
• W2765667906 cites W2042572544 @default.
• W2765667906 cites W2056801079 @default.
• W2765667906 cites W2060041568 @default.
• W2765667906 cites W2062259931 @default.
• W2765667906 cites W2066159172 @default.
• W2765667906 cites W2068532707 @default.
• W2765667906 cites W2075973812 @default.
• W2765667906 cites W2077216964 @default.
• W2765667906 cites W2083315396 @default.
• W2765667906 cites W2086102771 @default.
• W2765667906 cites W2091798744 @default.
• W2765667906 cites W2099110187 @default.
• W2765667906 cites W2099559429 @default.
• W2765667906 cites W2130247249 @default.
• W2765667906 cites W2135101522 @default.
• W2765667906 cites W2151763612 @default.
• W2765667906 cites W2152051874 @default.
• W2765667906 cites W2156360305 @default.
• W2765667906 cites W2160830606 @default.
• W2765667906 cites W2163643821 @default.
• W2765667906 cites W2332307736 @default.
• W2765667906 cites W2397818421 @default.
• W2765667906 cites W2407716352 @default.
• W2765667906 cites W2411952516 @default.
• W2765667906 cites W2511443137 @default.
• W2765667906 cites W2593775922 @default.
• W2765667906 cites W81244823 @default.
• W2765667906 cites W851185968 @default.
• W2765667906 doi "https://doi.org/10.1194/jlr.m079723" @default.
• W2765667906 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5711495" @default.
• W2765667906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29066466" @default.
• W2765667906 hasPublicationYear "2017" @default.
• W2765667906 type Work @default.
• W2765667906 sameAs 2765667906 @default.
• W2765667906 citedByCount "11" @default.
• W2765667906 countsByYear W27656679062018 @default.
• W2765667906 countsByYear W27656679062019 @default.
• W2765667906 countsByYear W27656679062020 @default.
• W2765667906 countsByYear W27656679062022 @default.
• W2765667906 crossrefType "journal-article" @default.
• W2765667906 hasAuthorship W2765667906A5000008605 @default.
• W2765667906 hasAuthorship W2765667906A5002484573 @default.
• W2765667906 hasAuthorship W2765667906A5019780697 @default.
• W2765667906 hasAuthorship W2765667906A5027492511 @default.
• W2765667906 hasAuthorship W2765667906A5034299091 @default.
• W2765667906 hasAuthorship W2765667906A5045077954 @default.
• W2765667906 hasAuthorship W2765667906A5059519671 @default.
• W2765667906 hasAuthorship W2765667906A5063215068 @default.
• W2765667906 hasAuthorship W2765667906A5063387242 @default.
• W2765667906 hasBestOaLocation W27656679061 @default.
• W2765667906 hasConcept C126322002 @default.
• W2765667906 hasConcept C134018914 @default.
• W2765667906 hasConcept C167414201 @default.
• W2765667906 hasConcept C171089720 @default.
• W2765667906 hasConcept C184235292 @default.
• W2765667906 hasConcept C185592680 @default.
• W2765667906 hasConcept C195794163 @default.
• W2765667906 hasConcept C2777180221 @default.
• W2765667906 hasConcept C2777391703 @default.
• W2765667906 hasConcept C2777866211 @default.
• W2765667906 hasConcept C2779306644 @default.
• W2765667906 hasConcept C2779959927 @default.
• W2765667906 hasConcept C3018667095 @default.
• W2765667906 hasConcept C36020004 @default.

• next