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• W2765669908 abstract "Amyloid-PET imaging with visual analysis is approved by the FDA for Alzheimer's disease (AD) diagnosis, but is technically complex, costly, and a radiation burden to patients. An alternative is measurement of cerebrospinal fluid (CSF) biomarkers β-Amyloid(1–42) (Aβ42), total tau (tTau), and phosphorylated tau (181P) (pTau), for which Roche Diagnostics is developing electrochemiluminescence immunoassays (Elecsys®). Using data from the BioFINDER and ADNI cohorts, we assessed whether the Elecsys® CSF biomarkers could reliably distinguish amyloid-PET-positive from -negative patients. We also compared visual-read amyloid-PET image analysis vs. the semi-quantitative, standardized uptake value ratios (SUVR) method. Patients had banked CSF samples and amyloid-PET images, as well as subjective cognitive decline or mild cognitive impairment (BioFINDER, N=277; 18Fflutemetamol) or mild cognitive impairment or subjective memory complaints, or AD (ADNI, N≈650; 18Fflorbetapir). Three independent readers, blinded to clinical data, visually evaluated amyloid-PET scans; amyloid-PET positivity was determined by majority assessment. Intra-reader reliability was determined based on re-ratings of approximately 10% of randomly selected images from available PET scans. Inter-reader reliability was also assessed. SUVRs were calculated in a standardized cortical region-of-interest using whole cerebellum as the reference region. CSF samples were analyzed using Elecsys® immunoassays for Aβ42, tTau, and pTau. Data from both ADNI and BioFINDER cohorts will be presented. For BioFINDER, intra-reader reliability based on average positive agreement (APA) and average negative agreement (ANA) was >90%. Inter-reader reliability gave an APA >80% and ANA >90%. Cut-off values for Aβ42, pTau/Aβ42, and tTau/Aβ42 were defined based on visual-read amyloid-PET positivity. The associated positive (PPA) and negative percentage agreements (NPA) at the cut-off value were 91% and 72% for Aβ42, and 91% and 89% for both pTau/Aβ42 and tTau/Aβ42, respectively. Higher concordance could be achieved with reference SUVR. We present a method to determine cut-off values of Elecsys® CSF immunoassays based on visual-read amyloid-PET positivity. The Elecsys® CSF immunoassays demonstrated excellent ability to predict amyloid-PET positivity, which was further improved by using tTau/Aβ42 and pTau/Aβ42 ratios compared to Aβ42 alone." @default.
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• W2765669908 date "2017-07-01" @default.
• W2765669908 modified "2023-10-16" @default.
• W2765669908 title "[O1–05–05]: AMYLOID‐PET CONCORDANCE OF ELECSYS® CSF BIOMARKER IMMUNOASSAYS FOR ALZHEIMER's DISEASE" @default.
• W2765669908 doi "https://doi.org/10.1016/j.jalz.2017.07.062" @default.
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