Matches in SemOpenAlex for { <https://semopenalex.org/work/W2765676402> ?p ?o ?g. }
- W2765676402 endingPage "12" @default.
- W2765676402 startingPage "1" @default.
- W2765676402 abstract "Coffee and nicotine consumption are frequently combined, indicating possible intensifying effect of caffeine on smoking behavior, although neurobiological background of this phenomenon remains unknown. We aimed at determining the effect of caffeine and nicotine, applied separately or simultaneously, on activation of six structures of the brain reward system: nucleus accumbens (NAc), ventral tegmental area (VTA), amygdala (Amg), hippocampus (Hip), medial prefrontal cortex (mPfr) and dorsal striatum (CdP) in the adult male Wistar rats. Activation of two transcription factors, the phosphorylated form of cyclic AMP-response element binding protein (pCREB) and DeltaFosB (ΔFosB) was assessed by immunohistochemistry after multiple-dose five-days psychostimulants administration followed by 20 min and 24 h survival, respectively. Nicotine evoked the highest increase of pCREB-immunoreactivity (-ir) in NAc, while caffeine exerted the weakest effect in mPfr and CdP. Nicotine/caffeine co-administration resulted in decrease of pCREB-ir in NAc and increase in Amg, compared with the effect of each psychostimulant used separately. Nicotine was the strongest psychostimulant activating ΔFosB-ir in Amg, whereas caffeine – in Hip. Nicotine/caffeine-exerted effect upon ΔFosB-ir in Amg was weaker, whereas in mPfr stronger, than nicotine-evoked effect in these structures. In summary, pCREB and ΔFosB activation is dependent on the type of stimulus, brain structure and functional context. Activation of both transcription factors is responsible for caffeine’s modifying effect upon nicotine-related behaviors and must be taken into account while quitting cigarette smoking." @default.
- W2765676402 created "2017-11-10" @default.
- W2765676402 creator A5001702173 @default.
- W2765676402 creator A5012783413 @default.
- W2765676402 creator A5026054992 @default.
- W2765676402 creator A5026506056 @default.
- W2765676402 creator A5037539904 @default.
- W2765676402 creator A5038948429 @default.
- W2765676402 creator A5047900656 @default.
- W2765676402 creator A5071532583 @default.
- W2765676402 date "2018-03-01" @default.
- W2765676402 modified "2023-10-18" @default.
- W2765676402 title "Nicotine-induced CREB and DeltaFosB activity is modified by caffeine in the brain reward system of the rat" @default.
- W2765676402 cites W1480391618 @default.
- W2765676402 cites W1489713305 @default.
- W2765676402 cites W1515108121 @default.
- W2765676402 cites W1529567719 @default.
- W2765676402 cites W1560942118 @default.
- W2765676402 cites W1963876508 @default.
- W2765676402 cites W1969515147 @default.
- W2765676402 cites W1969638746 @default.
- W2765676402 cites W1971015204 @default.
- W2765676402 cites W1980890656 @default.
- W2765676402 cites W1982243354 @default.
- W2765676402 cites W1996748355 @default.
- W2765676402 cites W2001410683 @default.
- W2765676402 cites W2008508054 @default.
- W2765676402 cites W2008857744 @default.
- W2765676402 cites W2010680036 @default.
- W2765676402 cites W2011935736 @default.
- W2765676402 cites W2025554865 @default.
- W2765676402 cites W2028149881 @default.
- W2765676402 cites W2028242823 @default.
- W2765676402 cites W2029051821 @default.
- W2765676402 cites W2041639784 @default.
- W2765676402 cites W2045192731 @default.
- W2765676402 cites W2049704911 @default.
- W2765676402 cites W2052611101 @default.
- W2765676402 cites W2053544091 @default.
- W2765676402 cites W2055319462 @default.
- W2765676402 cites W2058766183 @default.
- W2765676402 cites W2061443774 @default.
- W2765676402 cites W2064226140 @default.
- W2765676402 cites W2064371703 @default.
- W2765676402 cites W2064447463 @default.
- W2765676402 cites W2064679863 @default.
- W2765676402 cites W2066848874 @default.
- W2765676402 cites W2068412840 @default.
- W2765676402 cites W2071188129 @default.
- W2765676402 cites W2071743641 @default.
- W2765676402 cites W2075527287 @default.
- W2765676402 cites W2075856578 @default.
- W2765676402 cites W2076626681 @default.
- W2765676402 cites W2089657709 @default.
- W2765676402 cites W2092206787 @default.
- W2765676402 cites W2093589610 @default.
- W2765676402 cites W2094056330 @default.
- W2765676402 cites W2103392442 @default.
- W2765676402 cites W2104923476 @default.
- W2765676402 cites W2107218192 @default.
- W2765676402 cites W2109470880 @default.
- W2765676402 cites W2128430993 @default.
- W2765676402 cites W2135159454 @default.
- W2765676402 cites W2135412747 @default.
- W2765676402 cites W2141674392 @default.
- W2765676402 cites W2152851519 @default.
- W2765676402 cites W2156427101 @default.
- W2765676402 cites W2159447534 @default.
- W2765676402 cites W2236262897 @default.
- W2765676402 cites W2296574598 @default.
- W2765676402 cites W2409622791 @default.
- W2765676402 cites W4294730393 @default.
- W2765676402 cites W4319293047 @default.
- W2765676402 doi "https://doi.org/10.1016/j.jchemneu.2017.10.005" @default.
- W2765676402 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29100904" @default.
- W2765676402 hasPublicationYear "2018" @default.
- W2765676402 type Work @default.
- W2765676402 sameAs 2765676402 @default.
- W2765676402 citedByCount "7" @default.
- W2765676402 countsByYear W27656764022019 @default.
- W2765676402 countsByYear W27656764022020 @default.
- W2765676402 countsByYear W27656764022021 @default.
- W2765676402 countsByYear W27656764022022 @default.
- W2765676402 countsByYear W27656764022023 @default.
- W2765676402 crossrefType "journal-article" @default.
- W2765676402 hasAuthorship W2765676402A5001702173 @default.
- W2765676402 hasAuthorship W2765676402A5012783413 @default.
- W2765676402 hasAuthorship W2765676402A5026054992 @default.
- W2765676402 hasAuthorship W2765676402A5026506056 @default.
- W2765676402 hasAuthorship W2765676402A5037539904 @default.
- W2765676402 hasAuthorship W2765676402A5038948429 @default.
- W2765676402 hasAuthorship W2765676402A5047900656 @default.
- W2765676402 hasAuthorship W2765676402A5071532583 @default.
- W2765676402 hasConcept C104317684 @default.
- W2765676402 hasConcept C126322002 @default.
- W2765676402 hasConcept C134018914 @default.
- W2765676402 hasConcept C137183658 @default.
- W2765676402 hasConcept C151730666 @default.