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• W2765678580 abstract "Community-based cohort studies have suggested that associations with vascular risk measurements change in strength and direction closer in time to the onset of dementia. It has not yet been clarified whether these are evident in data derived from routine care. Using health records databases resources available through the European Medical Information Framework (EMIF) we sought to investigate differences between dementia cases and matched controls in systolic/diastolic blood pressure (SBP/DBP), body mass index (BMI) and cholesterol levels recorded at different time periods prior to the diagnosis date. We analysed records from four primary care datasets from the Netherlands (IPCI), Italy (HSD), Spain (SIDIAP) and UK (THIN), and one hospital care dataset from Jutland, Denmark (AUH). A total of 286,711 cases of dementia aged 50+ at diagnosis were compared to 28,661,163 controls – matched on age and gender at the date of diagnosis (index date). Previously recorded SBP/DBP, BMI and total serum cholesterol levels were compared within 7 periods prior to this index date (0–2, 2–4, 4–6, 6–8, 8–10, 10–12 years). Mean differences between cases and controls were calculated for each site and then combined by random effects meta-analyses for each time period. Data availability was highest for blood pressure, followed by cholesterol, and BMI; availability diminished with increasing time prior to the index date (Figure 1), and did not differ substantially between cases and controls. Mean differences in outcomes are displayed in Figures 2–5. Because of the large sample size, most meta-analysis points differed from the null at statistical significance. While lower BMI in cases became progressively more exaggerated closer to the index date, lower SBP showed stability over time periods, only becoming exaggerated at the most recent, and both DBP and cholesterol levels were not consistently different between cases and controls over time. In a uniquely large and heterogeneous set of health records data, we observed differences in BMI and SBP and trends over time that are consistent with exaggerated weight loss and decline in blood pressure prior to the onset of dementia. These need to be considered if dementia risk is estimated from clinical data. Mean data availability (%) across contributing sites for the specified time periods prior to the index date (first dementia diagnosis). Mean differences in BMI (kg/m2) between cases and controls at different intervals prior to dementia diagnosis date. Mean differences in serum cholesterol (mmol/l) between cases and controls at different intervals prior to dementia diagnosis date. Mean differences in systolic blood pressure (mmHg) between cases and controls at different intervals prior to dementia diagnosis date. Mean differences in diastolic blood pressure (mmHg) between cases and controls at different intervals prior to dementia diagnosis date." @default.
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• W2765678580 date "2017-07-01" @default.
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• W2765678580 title "[P4-341]: LEVELS OF BLOOD PRESSURE, BODY MASS INDEX AND TOTAL SERUM CHOLESTEROL AT DIFFERENT TIME POINTS PRIOR TO DEMENTIA DIAGNOSIS: A CASE CONTROL STUDY OF OVER 28 MILLION ELECTRONIC HEALTH RECORDS FROM THE EMIF EHR DATA RESOURCE" @default.
• W2765678580 doi "https://doi.org/10.1016/j.jalz.2017.06.2211" @default.
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