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- W2765679290 abstract "In addition to the hallmark α-synuclein aggregates, the neuropathology in Dementia with Lewy bodies (DLB) patients include β-amyloid and tau aggregates and synaptic changes. There are few prospective clinico-pathological studies. Neuropathological and neurochemical analyses were performed on brains of prospectively followed patients diagnosed with DLB, Parkinson's Disease Dementia (PDD) and Alzheimer's Disease (AD), respectively. Synaptic proteins were measured from brain and CSF samples by ELISA and Western blot. Clinical diagnosis of DLB was confirmed by neuropathology with sensitivity and specificity above 80%. However, in some cases DLB was misdiagnosed. Typically, these patients tended to develop core DLB features relatively late in the disease course while others presented no significant Lewy body pathology despite fulfilling the clinical criteria early. Several cases had fluctuating cognition, while others were presenting visual hallucinations combined with visual impairment. Marked changes of synaptic proteins were found in post-mortem DLB brains, with a pattern distinct from that observed in AD and PDD. Furthermore, we found altered concentrations of synaptic proteins in the CSF of patients with PD that were associated with both cognitive and motor symptoms. We are currently measuring these proteins in the CSF in a larger group of prospectively followed PD and DLB patients. Clinical DLB criteria have acceptable accuracy but need improvement. The pattern of synaptic protein changes, possibly together with structural and functional imaging, may provide a potential for further improving diagnostic accuracy and prognostic prediction of DLB." @default.
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- W2765679290 date "2017-07-01" @default.
- W2765679290 modified "2023-10-02" @default.
- W2765679290 title "CLINICO-PATHOLOGIC ASSOCIATIONS IN DLB: RELEVANCE FOR DIAGNOSIS AND TREATMENT" @default.
- W2765679290 doi "https://doi.org/10.1016/j.jalz.2017.07.479" @default.
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