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• W2765692827 startingPage "10258" @default.
• W2765692827 abstract "Oxidation and heat treatment can initiate changes in the amino acid composition, structure, solubility, hydrophobicity, conformation, function, and susceptibility to proteolysis of proteins. These can result in adverse consequences for mammals, plants, foodstuffs, and pharmaceuticals. This study investigated whether and how individual or combined treatment with heat, a commonly encountered factor in industrial processing, and H2O2 alters the structure and composition of two major milk whey proteins, α-lactalbumin and β-lactoglobulin, and mixtures of these. Thermal treatment induced reducible cross-links in isolated β-lactoglobulin, but not isolated α-lactalbumin under the conditions employed. Cross-linking occurred at lower temperatures and to a greater extent in the presence of low concentrations of H2O2. H2O2 did not induce cross-linking in the absence of heat. Mixtures of α-lactalbumin and β-lactoglobulin showed similar behavior, except that mixed α-lactalbumin−β-lactoglobulin dimers were detected. Cross-linking was associated with formation of sulfenic acids (RS–OH species), oxidation of methionine residues, cleavage of disulfide bonds in α-lactalbumin, altered conformation of disulfide bonds in β-lactoglobulin, alterations in the fluorescence intensity and maximum emission wavelength of endogenous tryptophan residues, and binding of the hydrophobic probe 8-anilinonaphthalenesulfonate. These data are consistent with increased unfolding and subsequent aggregation of the protein, with these changes being maximized in the presence of both heat and H2O2. The enhanced aggregation detected with H2O2 is consistent with additional pathways to aggregation above that induced by heat alone. These mechanistic insights provide potential strategies for modulating the extent and nature of protein modification induced by thermal and oxidant treatment." @default.
• W2765692827 created "2017-11-10" @default.
• W2765692827 creator A5005413573 @default.
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• W2765692827 date "2017-11-14" @default.
• W2765692827 modified "2023-10-16" @default.
• W2765692827 title "Effect of Oxidation and Protein Unfolding on Cross-Linking of β-Lactoglobulin and α-Lactalbumin" @default.
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• W2765692827 doi "https://doi.org/10.1021/acs.jafc.7b03839" @default.
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