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- W2765697352 abstract "Abstract Objective Studies have indicated that both increased and suppressed immune system activity may affect depression severity. We tested the hypothesis that higher or lower white blood cell (WBC) count at first depression diagnosis is associated with an increased risk of hospitalization with depression. Methods We identified individuals in a hospital-affiliated primary care network with a WBC count at the first-time depression diagnosis in 2006–2011. Outcome was subsequent hospitalization with depression. We followed individuals for three years and performed Cox regression analyses adjusted for age, gender, race, Charlson comorbidity score, obesity, and smoking. Significance was set at p Results We identified 2400 individuals with a mean WBC count of 7.1 × 109/L at first-time depression diagnosis, of which 55 were hospitalized with depression. Compared to WBC between 4.5–6 × 109/L, individuals with WBC of 1–4.5 × 109/L were associated with a hazard rate (HR) of 3.56 (95%CI = 1.02-12.39; p = 0.046) for the risk of hospitalization with depression. Individuals with WBC of 6–10 × 109/L were associated with a HR of 2.62 (95%CI = 1.02-6.71, p = 0.044) whereas no association was found among individuals with WBC of 10–25 × 109/L (HR = 1.81; 95%CI = 0.54-6.07). Conclusions Our results are in line with previous clinical findings showing that the severity of depression differs based on WBC counts, particularly concerning low WBC levels. Future large clinical trials need to investigate whether WBC may help in prediction of antidepressant treatment outcome." @default.
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- W2765697352 date "2017-12-01" @default.
- W2765697352 modified "2023-09-25" @default.
- W2765697352 title "White blood cell count at first depression diagnosis as predictor for risk of subsequent hospitalization with depression" @default.
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- W2765697352 doi "https://doi.org/10.1016/j.npbr.2017.10.002" @default.
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