FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2765715993> ?p ?o ?g. }

• W2765715993 endingPage "69" @default.
• W2765715993 startingPage "62" @default.
• W2765715993 abstract "A partial response (PR) has been proposed as a surrogate for overall survival in advanced adrenocortical carcinoma (ACC). The primary endpoint of the study was to characterize the time until a PR in patients with metastatic ACC treated with a standard therapy is achieved. Long-term survivors were selected to allow evaluation of delayed tumor response to mitotane. Records from patients with metastatic ACC that survived for > 24 months were retrieved. Tumor response was analyzed according to the Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 criteria. Time until a tumor response, after treatment initiation or therapeutic plasma mitotane level, was analyzed. Sixty-eight patients were analyzed. The first-line systemic therapy was mitotane as a monotherapy (M) (n = 57) or cytotoxic polychemotherapy plus/minus mitotane (PC ± M) (n = 11). The second-line therapy was M (n = 2) or PC ± M (n = 41). Thirty-two PRs occurred in 30/68 patients (44.1%): this was obtained for 13 (40.6%) during M and during PC ± M for 19/32 responders (59.4%). PRs were observed within 6 months of starting M or PC ± M in 76.9 and 94.7% of responses, respectively, within 6 months of therapeutic plasma mitotane being first observed in 88.9% of responses with M and in 53.3% of responses with PC ± M. All PRs (but one) occurred within 1 year after initiating treatment. To conclude, Most patients with metastatic ACC and long survival times had PRs within the first 6 months of standard systemic therapy, and almost all within the first year. The absence of response after that period could be considered as a treatment failure. Maintenance of mitotane therapy in non-responders after 1 year should be questioned in future randomized trials." @default.
• W2765715993 created "2017-11-10" @default.
• W2765715993 creator A5000908628 @default.
• W2765715993 creator A5005646626 @default.
• W2765715993 creator A5008529320 @default.
• W2765715993 creator A5009623017 @default.
• W2765715993 creator A5011298568 @default.
• W2765715993 creator A5015697378 @default.
• W2765715993 creator A5024262598 @default.
• W2765715993 creator A5029587078 @default.
• W2765715993 creator A5032622658 @default.
• W2765715993 creator A5041250553 @default.
• W2765715993 creator A5044089887 @default.
• W2765715993 creator A5051115285 @default.
• W2765715993 creator A5055028996 @default.
• W2765715993 creator A5056105163 @default.
• W2765715993 creator A5060536774 @default.
• W2765715993 creator A5065286040 @default.
• W2765715993 creator A5067116958 @default.
• W2765715993 creator A5077171092 @default.
• W2765715993 creator A5081409867 @default.
• W2765715993 date "2017-10-25" @default.
• W2765715993 modified "2023-10-13" @default.
• W2765715993 title "Time Until Partial Response in Metastatic Adrenocortical Carcinoma Long-Term Survivors" @default.
• W2765715993 cites W1969723784 @default.
• W2765715993 cites W1994325777 @default.
• W2765715993 cites W1995124360 @default.
• W2765715993 cites W2014346670 @default.
• W2765715993 cites W2019607817 @default.
• W2765715993 cites W2079874148 @default.
• W2765715993 cites W2089817687 @default.
• W2765715993 cites W2108273340 @default.
• W2765715993 cites W2114819486 @default.
• W2765715993 cites W2122095127 @default.
• W2765715993 cites W2142931016 @default.
• W2765715993 cites W2175623323 @default.
• W2765715993 cites W2223265747 @default.
• W2765715993 cites W2326550013 @default.
• W2765715993 cites W2336089418 @default.
• W2765715993 cites W4211189907 @default.
• W2765715993 doi "https://doi.org/10.1007/s12672-017-0313-6" @default.
• W2765715993 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29071575" @default.
• W2765715993 hasPublicationYear "2017" @default.
• W2765715993 type Work @default.
• W2765715993 sameAs 2765715993 @default.
• W2765715993 citedByCount "18" @default.
• W2765715993 countsByYear W27657159932018 @default.
• W2765715993 countsByYear W27657159932019 @default.
• W2765715993 countsByYear W27657159932020 @default.
• W2765715993 countsByYear W27657159932021 @default.
• W2765715993 countsByYear W27657159932022 @default.
• W2765715993 countsByYear W27657159932023 @default.
• W2765715993 crossrefType "journal-article" @default.
• W2765715993 hasAuthorship W2765715993A5000908628 @default.
• W2765715993 hasAuthorship W2765715993A5005646626 @default.
• W2765715993 hasAuthorship W2765715993A5008529320 @default.
• W2765715993 hasAuthorship W2765715993A5009623017 @default.
• W2765715993 hasAuthorship W2765715993A5011298568 @default.
• W2765715993 hasAuthorship W2765715993A5015697378 @default.
• W2765715993 hasAuthorship W2765715993A5024262598 @default.
• W2765715993 hasAuthorship W2765715993A5029587078 @default.
• W2765715993 hasAuthorship W2765715993A5032622658 @default.
• W2765715993 hasAuthorship W2765715993A5041250553 @default.
• W2765715993 hasAuthorship W2765715993A5044089887 @default.
• W2765715993 hasAuthorship W2765715993A5051115285 @default.
• W2765715993 hasAuthorship W2765715993A5055028996 @default.
• W2765715993 hasAuthorship W2765715993A5056105163 @default.
• W2765715993 hasAuthorship W2765715993A5060536774 @default.
• W2765715993 hasAuthorship W2765715993A5065286040 @default.
• W2765715993 hasAuthorship W2765715993A5067116958 @default.
• W2765715993 hasAuthorship W2765715993A5077171092 @default.
• W2765715993 hasAuthorship W2765715993A5081409867 @default.
• W2765715993 hasBestOaLocation W27657159931 @default.
• W2765715993 hasConcept C121608353 @default.
• W2765715993 hasConcept C126322002 @default.
• W2765715993 hasConcept C126894567 @default.
• W2765715993 hasConcept C143998085 @default.
• W2765715993 hasConcept C185926286 @default.
• W2765715993 hasConcept C203092338 @default.
• W2765715993 hasConcept C2776694085 @default.
• W2765715993 hasConcept C2776735609 @default.
• W2765715993 hasConcept C2777546739 @default.
• W2765715993 hasConcept C2778822529 @default.
• W2765715993 hasConcept C2779013556 @default.
• W2765715993 hasConcept C2779984678 @default.
• W2765715993 hasConcept C2780283643 @default.
• W2765715993 hasConcept C2781399356 @default.
• W2765715993 hasConcept C3019096185 @default.
• W2765715993 hasConcept C530470458 @default.
• W2765715993 hasConcept C535046627 @default.
• W2765715993 hasConcept C71924100 @default.
• W2765715993 hasConcept C90924648 @default.
• W2765715993 hasConceptScore W2765715993C121608353 @default.
• W2765715993 hasConceptScore W2765715993C126322002 @default.
• W2765715993 hasConceptScore W2765715993C126894567 @default.
• W2765715993 hasConceptScore W2765715993C143998085 @default.
• W2765715993 hasConceptScore W2765715993C185926286 @default.
• W2765715993 hasConceptScore W2765715993C203092338 @default.

• next