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- W2765720579 abstract "To address the growing need for new antimicrobial agents, we explored whether inhibition of bacterial signaling machinery could inhibit bacterial growth. Because bacteria rely on two-component signaling systems to respond to environmental changes, and because these systems are both highly conserved and mediated by histidine kinases, inhibiting histidine kinases may provide broad spectrum antimicrobial activity. The histidine kinase ATP binding domain is conserved with the ATPase domain of eukaryotic Hsp90 molecular chaperones. To find a chemical scaffold for compounds that target histidine kinases, we leveraged this conservation. We screened ATP competitive Hsp90 inhibitors against CckA, an essential histidine kinase in Caulobacter crescentus that controls cell growth, and showed that the diaryl pyrazole is a promising scaffold for histidine kinase inhibition. We synthesized a panel of derivatives and found that they inhibit the histidine kinases C. crescentus CckA and Salmonella PhoQ but not C. crescentus DivJ; and they inhibit bacterial growth in both Gram-negative and Gram-positive bacterial strains." @default.
- W2765720579 created "2017-11-10" @default.
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- W2765720579 date "2017-12-01" @default.
- W2765720579 modified "2023-09-26" @default.
- W2765720579 title "Repurposing Hsp90 inhibitors as antibiotics targeting histidine kinases" @default.
- W2765720579 cites W1507853369 @default.
- W2765720579 cites W1533371356 @default.
- W2765720579 cites W1560576352 @default.
- W2765720579 cites W1568333329 @default.
- W2765720579 cites W174107104 @default.
- W2765720579 cites W1791474524 @default.
- W2765720579 cites W1861243942 @default.
- W2765720579 cites W1965787931 @default.
- W2765720579 cites W1966350980 @default.
- W2765720579 cites W1969608656 @default.
- W2765720579 cites W1979973356 @default.
- W2765720579 cites W1998744918 @default.
- W2765720579 cites W1998863708 @default.
- W2765720579 cites W1999189021 @default.
- W2765720579 cites W1999715990 @default.
- W2765720579 cites W2000106654 @default.
- W2765720579 cites W2000843502 @default.
- W2765720579 cites W2001858185 @default.
- W2765720579 cites W2003805073 @default.
- W2765720579 cites W2006002169 @default.
- W2765720579 cites W2007119688 @default.
- W2765720579 cites W2009015255 @default.
- W2765720579 cites W2012520981 @default.
- W2765720579 cites W2027298376 @default.
- W2765720579 cites W2031414855 @default.
- W2765720579 cites W2038846224 @default.
- W2765720579 cites W2047132220 @default.
- W2765720579 cites W2047458120 @default.
- W2765720579 cites W2051060071 @default.
- W2765720579 cites W2062730181 @default.
- W2765720579 cites W2075983346 @default.
- W2765720579 cites W2078544581 @default.
- W2765720579 cites W2081929574 @default.
- W2765720579 cites W2082366293 @default.
- W2765720579 cites W2090635804 @default.
- W2765720579 cites W2094566428 @default.
- W2765720579 cites W2102543221 @default.
- W2765720579 cites W2105238785 @default.
- W2765720579 cites W2106144388 @default.
- W2765720579 cites W2108559568 @default.
- W2765720579 cites W2112133866 @default.
- W2765720579 cites W2113557404 @default.
- W2765720579 cites W2114167010 @default.
- W2765720579 cites W2118291047 @default.
- W2765720579 cites W2118405368 @default.
- W2765720579 cites W2123885130 @default.
- W2765720579 cites W2125112034 @default.
- W2765720579 cites W2125634299 @default.
- W2765720579 cites W2126225963 @default.
- W2765720579 cites W2127287358 @default.
- W2765720579 cites W2131170296 @default.
- W2765720579 cites W2132629607 @default.
- W2765720579 cites W2136401310 @default.
- W2765720579 cites W2140353364 @default.
- W2765720579 cites W2142672063 @default.
- W2765720579 cites W2143550120 @default.
- W2765720579 cites W2146538795 @default.
- W2765720579 cites W2148584610 @default.
- W2765720579 cites W2152856606 @default.
- W2765720579 cites W2159452130 @default.
- W2765720579 cites W2160170449 @default.
- W2765720579 cites W2161347773 @default.
- W2765720579 cites W2161994209 @default.
- W2765720579 cites W2164367233 @default.
- W2765720579 cites W2164997719 @default.
- W2765720579 cites W2169940011 @default.
- W2765720579 cites W2274492110 @default.
- W2765720579 cites W2301270613 @default.
- W2765720579 cites W2342958208 @default.
- W2765720579 cites W2382474752 @default.
- W2765720579 cites W2394227909 @default.
- W2765720579 cites W2417397441 @default.
- W2765720579 cites W2512611538 @default.
- W2765720579 cites W2520436329 @default.
- W2765720579 cites W2529048117 @default.
- W2765720579 cites W2592604470 @default.
- W2765720579 cites W2603712933 @default.