FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2765731608> ?p ?o ?g. }

• W2765731608 endingPage "11890" @default.
• W2765731608 startingPage "11878" @default.
• W2765731608 abstract "The single-stranded DNA binding protein (SSB) of Escherichia coli plays essential roles in maintaining genome integrity by sequestering ssDNA and mediating DNA processing pathways through interactions with DNA-processing enzymes. Despite its DNA-sequestering properties, SSB stimulates the DNA processing activities of some of its binding partners. One example is the genome maintenance protein RecQ helicase. Here, we determine the mechanistic details of the RecQ-SSB interaction using single-molecule magnetic tweezers and rapid kinetic experiments. Our results reveal that the SSB-RecQ interaction changes the binding mode of SSB, thereby allowing RecQ to gain access to ssDNA and facilitating DNA unwinding. Conversely, the interaction of RecQ with the SSB C-terminal tail increases the on-rate of RecQ-DNA binding and has a modest stimulatory effect on the unwinding rate of RecQ. We propose that this bidirectional communication promotes efficient DNA processing and explains how SSB stimulates rather than inhibits RecQ activity." @default.
• W2765731608 created "2017-11-10" @default.
• W2765731608 creator A5001218635 @default.
• W2765731608 creator A5008997812 @default.
• W2765731608 creator A5014297467 @default.
• W2765731608 creator A5038534532 @default.
• W2765731608 creator A5044310454 @default.
• W2765731608 creator A5067293156 @default.
• W2765731608 creator A5070817529 @default.
• W2765731608 creator A5084355089 @default.
• W2765731608 date "2017-10-20" @default.
• W2765731608 modified "2023-10-17" @default.
• W2765731608 title "RecQ helicase triggers a binding mode change in the SSB–DNA complex to efficiently initiate DNA unwinding" @default.
• W2765731608 cites W1505415846 @default.
• W2765731608 cites W1699817896 @default.
• W2765731608 cites W1785625799 @default.
• W2765731608 cites W1806123628 @default.
• W2765731608 cites W1924027056 @default.
• W2765731608 cites W1945756523 @default.
• W2765731608 cites W1966260649 @default.
• W2765731608 cites W1968810666 @default.
• W2765731608 cites W1971178460 @default.
• W2765731608 cites W1975853779 @default.
• W2765731608 cites W1977109739 @default.
• W2765731608 cites W1981829426 @default.
• W2765731608 cites W1983127291 @default.
• W2765731608 cites W1986104253 @default.
• W2765731608 cites W1989108993 @default.
• W2765731608 cites W1992140093 @default.
• W2765731608 cites W2001733153 @default.
• W2765731608 cites W2006299598 @default.
• W2765731608 cites W2011351273 @default.
• W2765731608 cites W2023385023 @default.
• W2765731608 cites W2024922257 @default.
• W2765731608 cites W2025192084 @default.
• W2765731608 cites W2026957636 @default.
• W2765731608 cites W2030639168 @default.
• W2765731608 cites W2032162552 @default.
• W2765731608 cites W2033891762 @default.
• W2765731608 cites W2035832119 @default.
• W2765731608 cites W2039751418 @default.
• W2765731608 cites W2044016235 @default.
• W2765731608 cites W2052738967 @default.
• W2765731608 cites W2061713612 @default.
• W2765731608 cites W2063335759 @default.
• W2765731608 cites W2066638568 @default.
• W2765731608 cites W2069361954 @default.
• W2765731608 cites W2070117236 @default.
• W2765731608 cites W2072052386 @default.
• W2765731608 cites W2074125914 @default.
• W2765731608 cites W2075442976 @default.
• W2765731608 cites W2082129123 @default.
• W2765731608 cites W2085214569 @default.
• W2765731608 cites W2086635651 @default.
• W2765731608 cites W2087174347 @default.
• W2765731608 cites W2090024664 @default.
• W2765731608 cites W2091928826 @default.
• W2765731608 cites W2093358373 @default.
• W2765731608 cites W2097038081 @default.
• W2765731608 cites W2097507625 @default.
• W2765731608 cites W2099764109 @default.
• W2765731608 cites W2100489858 @default.
• W2765731608 cites W2101330556 @default.
• W2765731608 cites W2107856831 @default.
• W2765731608 cites W2115684167 @default.
• W2765731608 cites W2116711646 @default.
• W2765731608 cites W2119862706 @default.
• W2765731608 cites W2126192932 @default.
• W2765731608 cites W2127392515 @default.
• W2765731608 cites W2131737890 @default.
• W2765731608 cites W2132860946 @default.
• W2765731608 cites W2135006530 @default.
• W2765731608 cites W2135453449 @default.
• W2765731608 cites W2138076097 @default.
• W2765731608 cites W2148330718 @default.
• W2765731608 cites W2153436893 @default.
• W2765731608 cites W2156463609 @default.
• W2765731608 cites W2159889468 @default.
• W2765731608 cites W2161467914 @default.
• W2765731608 cites W2165108940 @default.
• W2765731608 cites W2178168667 @default.
• W2765731608 cites W2336337601 @default.
• W2765731608 cites W2344671021 @default.
• W2765731608 cites W2568264723 @default.
• W2765731608 cites W4232090872 @default.
• W2765731608 cites W641367060 @default.
• W2765731608 doi "https://doi.org/10.1093/nar/gkx939" @default.
• W2765731608 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5714189" @default.
• W2765731608 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29059328" @default.
• W2765731608 hasPublicationYear "2017" @default.
• W2765731608 type Work @default.
• W2765731608 sameAs 2765731608 @default.
• W2765731608 citedByCount "22" @default.
• W2765731608 countsByYear W27657316082018 @default.
• W2765731608 countsByYear W27657316082019 @default.
• W2765731608 countsByYear W27657316082020 @default.
• W2765731608 countsByYear W27657316082021 @default.
• W2765731608 countsByYear W27657316082022 @default.

• next