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- W2765732503 abstract "The chronic cerebral ischemia and hypoxemic damage of neurons, which is frequently caused by atherosclerosis and arterial hypertension, stimulate development of vascular dementia. The impairment in learning, memory functions, cognitive skills, emotions and quality of life are usually associated with injury of hippocampal neurons and synaptic plasticity. Chronic cerebral ischemia was modeled in rats using a gravitational overload with a force of 9 G in a caudo-cranial vector for 5 minutes twice per day with interval of 12 hours for 28 days. The behavioral status, cognitive functions and memory, the nature of damage of neurons and level of an expression of glial fibrillary acidic protein (GFAP) in brain paraffin sections were measured. After 28 days of chronic cerebral ischemia modeling functional and morphological manifestations of vascular dementia in rats were noted. Cognitive violations manifested by decrease in orienting-exploratory activity, decrease in memory and ability to memorize new objects, decreasing in safety of main reflexes were also found. Significant increased amount of pyknotic neurons and neurons with the hyperchromatosis of cytoplasm in perikarya in all zones of hippocampus (p<0.05) were revealed. Decrease in relative density of pyramidal neurons (p<0.05) and focal loss of neurons of pyramidal layer, pericellular edema were combined with increased expression of GFAP in astrocytes of CA2 and CA4. The cognitive violations and behavioral disorders found in the functional tests in vascular dementia modeling are caused by both reversible and irreversible progressing injuries of hyppocampal neurons. Decrease of pyramidal neurons relative density and increase in expression of GFAP in CA2 and CA4 demonstrates the emergence of neurodegenerative changes, activation of astrocytes and gliosis in these zones." @default.
- W2765732503 created "2017-11-10" @default.
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- W2765732503 date "2017-07-01" @default.
- W2765732503 modified "2023-09-27" @default.
- W2765732503 title "[P2-439]: NEURONAL AND GLIAL CHANGES IN HIPPOCAMPUS IN MODEL OF CHRONIC CEREBRAL ISCHEMIA" @default.
- W2765732503 doi "https://doi.org/10.1016/j.jalz.2017.06.1095" @default.
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