Matches in SemOpenAlex for { <https://semopenalex.org/work/W2765742569> ?p ?o ?g. }
Showing items 1 to 59 of
59
with 100 items per page.
- W2765742569 abstract "Cisplatin, a commonly used chemotherapeutic, is limited on it efficacy due to the rapid development of resistance. A common underlying factor in the development of this resistance is a decrease in cellular accumulation of the drug. Recent studies have suggested that the copper transport pathway may be responsible for the uptake and cellular trafficking of cisplatin. The overall goal of the studies described here was to determine whether the Cu plasma membrane transporter hCTR1 plays a role in the cellular accumulation of cisplatin, and if so, whether it influences the sensitivity of cells to this common chemotherapy. This was achieved by using two cellular models, one in which hCTR1 was over expressed and the other in which CTR1 was absent. Once hCTR1 was identified as an influx transporter of DDP, investigations went on to identify the cellular regulation and trafficking of the protein through the use of chemical inhibitors and dominant negative mutants to block normal endocytotic and proteasomal pathways. The role that hCTR1 may play in the resistance of human tumors to cisplatin was investigated using cisplatin sensitive and resistant ovarian carcinoma cell lines and the screening of human tumor tissue. The experiments described in the following work demonstrate that hCTR1 plays a role in the transport of cisplatin, as alterations of hCTR1 protein levels correspond to platinum accumulation levels. While hCTR1 does appear to influence cisplatin, the results presented here indicate that hCTR1 does not necessary correlate to drug sensitivity in human cells, as hCTR1 levels were not significantly altered for normal tissue in a majority of human tumors or in sensitive and resistant cell pairs. Finally, the cellular trafficking of hCTR1 depends on the continual cycling of the protein. However, up on exposure to DDP, hCTR1 is rapidly internalized through macropinocytosis and degraded by the proteasome" @default.
- W2765742569 created "2017-11-10" @default.
- W2765742569 creator A5070549449 @default.
- W2765742569 date "2006-01-01" @default.
- W2765742569 modified "2023-09-27" @default.
- W2765742569 title "The regulation of the human copper transporter 1 and its role in the cellular uptake of Cisplatin - eScholarship" @default.
- W2765742569 hasPublicationYear "2006" @default.
- W2765742569 type Work @default.
- W2765742569 sameAs 2765742569 @default.
- W2765742569 citedByCount "0" @default.
- W2765742569 crossrefType "journal-article" @default.
- W2765742569 hasAuthorship W2765742569A5070549449 @default.
- W2765742569 hasConcept C104317684 @default.
- W2765742569 hasConcept C143065580 @default.
- W2765742569 hasConcept C149011108 @default.
- W2765742569 hasConcept C185592680 @default.
- W2765742569 hasConcept C200082930 @default.
- W2765742569 hasConcept C2776694085 @default.
- W2765742569 hasConcept C2778239845 @default.
- W2765742569 hasConcept C502942594 @default.
- W2765742569 hasConcept C54355233 @default.
- W2765742569 hasConcept C55493867 @default.
- W2765742569 hasConcept C81885089 @default.
- W2765742569 hasConcept C86803240 @default.
- W2765742569 hasConceptScore W2765742569C104317684 @default.
- W2765742569 hasConceptScore W2765742569C143065580 @default.
- W2765742569 hasConceptScore W2765742569C149011108 @default.
- W2765742569 hasConceptScore W2765742569C185592680 @default.
- W2765742569 hasConceptScore W2765742569C200082930 @default.
- W2765742569 hasConceptScore W2765742569C2776694085 @default.
- W2765742569 hasConceptScore W2765742569C2778239845 @default.
- W2765742569 hasConceptScore W2765742569C502942594 @default.
- W2765742569 hasConceptScore W2765742569C54355233 @default.
- W2765742569 hasConceptScore W2765742569C55493867 @default.
- W2765742569 hasConceptScore W2765742569C81885089 @default.
- W2765742569 hasConceptScore W2765742569C86803240 @default.
- W2765742569 hasLocation W27657425691 @default.
- W2765742569 hasOpenAccess W2765742569 @default.
- W2765742569 hasPrimaryLocation W27657425691 @default.
- W2765742569 hasRelatedWork W1503912124 @default.
- W2765742569 hasRelatedWork W1976611938 @default.
- W2765742569 hasRelatedWork W1981079665 @default.
- W2765742569 hasRelatedWork W1999839463 @default.
- W2765742569 hasRelatedWork W2057882999 @default.
- W2765742569 hasRelatedWork W2274573412 @default.
- W2765742569 hasRelatedWork W2339283357 @default.
- W2765742569 hasRelatedWork W2398889007 @default.
- W2765742569 hasRelatedWork W2419059585 @default.
- W2765742569 hasRelatedWork W2588461271 @default.
- W2765742569 hasRelatedWork W2767128515 @default.
- W2765742569 hasRelatedWork W278601133 @default.
- W2765742569 hasRelatedWork W3014538928 @default.
- W2765742569 hasRelatedWork W3042654301 @default.
- W2765742569 hasRelatedWork W3113706909 @default.
- W2765742569 hasRelatedWork W177814923 @default.
- W2765742569 isParatext "false" @default.
- W2765742569 isRetracted "false" @default.
- W2765742569 magId "2765742569" @default.
- W2765742569 workType "article" @default.