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• W2765746018 abstract "MicroRNAs are important regulators of the pathogenesis of B-cell acute lymphoblastic leukaemia (B-ALL). In this study, we identified miR-3173 and its predicted target gene PTK2 were correspondingly differentially expressed in B-ALL patients. In B-ALL cell lines, CCK-8 proliferation assay revealed that miR-3173 could inhibit the cell proliferation. Moreover, transwell assay revealed that miR-3173 could also inhibit cell migration and invasion in B-ALL cell lines. Luciferase assays revealed that miR-3173 directly bound to the 3'untranslated region of PTK2, and western blotting showed that miR-3173 suppressed the expression of PTK2 at the protein level. Generally, this study indicates that miR-3173 negatively regulates PTK2 and inhibits proliferation and invasion of B-ALL cell lines. Thus, miR-3173 may represent a potential therapeutic molecule for B-ALL intervention." @default.
• W2765746018 created "2017-11-10" @default.
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• W2765746018 date "2017-12-01" @default.
• W2765746018 modified "2023-09-26" @default.
• W2765746018 title "The downregulation of miR-3173 in B-cell acute lymphoblastic leukaemia promotes cell invasion via PTK2" @default.
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• W2765746018 doi "https://doi.org/10.1016/j.bbrc.2017.10.013" @default.
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