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- W2765748077 abstract "Chitosan/silk fibroin/glycerophosphate gels were loaded with nerve growth factor (NGF) and further processed into multi-tubule fillers. NGF was loaded into the fillers in such a way so that a NGF gradient was established longitudinally along the filler length. A type of poly(lactide-co-glycolide)(PLGA)/chitosan(CH) porous conduit was fabricated using a pre-crosslinking method. The filler was fully filled into the lumen of conduits to build multi-tubule conduit-filler constructs that are intended for long-gap peripheral nerve repair. In vitro degradation in a lysozyme-contained medium revealed that constructs had degradation-tolerant features and the optimized multi-tubule filler was capable of maintaining its multi-tubules unblocked for around 10-week. After being degraded for various periods up to 8 weeks, the optimal conduit-filler constructs showed confirmative ability to retain their compressive load, deformation recovery and tensile strength at about 80N/m, 75% and 15N/cm2 in wet state, respectively. The constructs were able to administer NGF release and to maintain persistent NGF gradients longitudinally distributed inside the PLGA/CH conduit for about 6 weeks or even longer. The PC12 cell neurite extension assay confirmed that the presently developed multi-tubule conduit-filler constructs were reliable for effectively preserving the bioactivity of released NGF." @default.
- W2765748077 created "2017-11-10" @default.
- W2765748077 creator A5015807648 @default.
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- W2765748077 date "2018-01-01" @default.
- W2765748077 modified "2023-09-26" @default.
- W2765748077 title "Multi-tubule conduit-filler constructs loaded with gradient-distributed growth factors for neural tissue engineering applications" @default.
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- W2765748077 doi "https://doi.org/10.1016/j.jmbbm.2017.10.031" @default.
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