Matches in SemOpenAlex for { <https://semopenalex.org/work/W2765754570> ?p ?o ?g. }
- W2765754570 endingPage "51" @default.
- W2765754570 startingPage "44" @default.
- W2765754570 abstract "For several decades, the leukotriene pathways have been implicated as playing a central role in the pathophysiology of asthma. The presence and elevation of numerous metabolites in the blood, sputum, and bronchoalveolar lavage fluid from asthmatics or experimental animals adds support to this notion. However, targeting of the leukotriene pathways has had, in general, limited success. The single exception in asthma therapy has been targeting of the cysteinyl leukotriene receptor 1, which clinically has proven effective but only in certain clinical situations. Interference with 5-lipoxygenase has had limited success, in part due to adverse drug effects. The importance of the LTB4-BLT1 pathway in asthma pathogenesis has extensive experimental support and findings, albeit limited, from clinical samples. The LTB4-BLT1 pathway was shown to be important as a neutrophil chemoattractant. Despite observations made more than two decades ago, the LTB4-BLT1 pathway has only recently been shown to exhibit important activities on subsets of T lymphocytes, both as a chemoattractant and on lymphocyte activation, as well as on dendritic cells, the major antigen presenting cell in the lung. The role of BLT2 in asthma remains unclear. Targeting of components of the LTB4-BLT1 pathway offers innovative therapeutic opportunities especially in patients with asthma that remain uncontrolled despite intensive corticosteroid treatment." @default.
- W2765754570 created "2017-11-10" @default.
- W2765754570 creator A5023960478 @default.
- W2765754570 date "2017-10-01" @default.
- W2765754570 modified "2023-10-15" @default.
- W2765754570 title "Importance of the leukotriene B4-BLT1 and LTB4-BLT2 pathways in asthma" @default.
- W2765754570 cites W1503258737 @default.
- W2765754570 cites W1505976169 @default.
- W2765754570 cites W1524689497 @default.
- W2765754570 cites W1526825773 @default.
- W2765754570 cites W1541644834 @default.
- W2765754570 cites W1549199956 @default.
- W2765754570 cites W1561018825 @default.
- W2765754570 cites W1567770396 @default.
- W2765754570 cites W1596062304 @default.
- W2765754570 cites W1603889483 @default.
- W2765754570 cites W1661544713 @default.
- W2765754570 cites W1665185236 @default.
- W2765754570 cites W1671834350 @default.
- W2765754570 cites W1672565987 @default.
- W2765754570 cites W1823700311 @default.
- W2765754570 cites W1949018824 @default.
- W2765754570 cites W1968098118 @default.
- W2765754570 cites W1968723792 @default.
- W2765754570 cites W1972134778 @default.
- W2765754570 cites W1975832104 @default.
- W2765754570 cites W1978265095 @default.
- W2765754570 cites W1979374866 @default.
- W2765754570 cites W1979415936 @default.
- W2765754570 cites W1981480494 @default.
- W2765754570 cites W1983180803 @default.
- W2765754570 cites W1983397523 @default.
- W2765754570 cites W1985405157 @default.
- W2765754570 cites W1992622607 @default.
- W2765754570 cites W1995124093 @default.
- W2765754570 cites W1995440419 @default.
- W2765754570 cites W1997561160 @default.
- W2765754570 cites W2001145791 @default.
- W2765754570 cites W2002089165 @default.
- W2765754570 cites W2004351423 @default.
- W2765754570 cites W2005301744 @default.
- W2765754570 cites W2006147589 @default.
- W2765754570 cites W2011447582 @default.
- W2765754570 cites W2011577549 @default.
- W2765754570 cites W2015006881 @default.
- W2765754570 cites W2022764554 @default.
- W2765754570 cites W2023213942 @default.
- W2765754570 cites W2023814037 @default.
- W2765754570 cites W2029245561 @default.
- W2765754570 cites W2029335276 @default.
- W2765754570 cites W2035036279 @default.
- W2765754570 cites W2037380046 @default.
- W2765754570 cites W2040243459 @default.
- W2765754570 cites W2041385557 @default.
- W2765754570 cites W2042501384 @default.
- W2765754570 cites W2043008520 @default.
- W2765754570 cites W2044029073 @default.
- W2765754570 cites W2045744166 @default.
- W2765754570 cites W2047202466 @default.
- W2765754570 cites W2047267265 @default.
- W2765754570 cites W2052395623 @default.
- W2765754570 cites W2058661991 @default.
- W2765754570 cites W2063803056 @default.
- W2765754570 cites W2069193463 @default.
- W2765754570 cites W2069353968 @default.
- W2765754570 cites W2070065588 @default.
- W2765754570 cites W2077884399 @default.
- W2765754570 cites W2078039240 @default.
- W2765754570 cites W2081097093 @default.
- W2765754570 cites W2083057314 @default.
- W2765754570 cites W2083566679 @default.
- W2765754570 cites W2089393518 @default.
- W2765754570 cites W2090837742 @default.
- W2765754570 cites W2096025192 @default.
- W2765754570 cites W2097407366 @default.
- W2765754570 cites W2097702927 @default.
- W2765754570 cites W2098727834 @default.
- W2765754570 cites W2106234499 @default.
- W2765754570 cites W2106824759 @default.
- W2765754570 cites W2106827191 @default.
- W2765754570 cites W2112552541 @default.
- W2765754570 cites W2116105539 @default.
- W2765754570 cites W2124714277 @default.
- W2765754570 cites W2130112063 @default.
- W2765754570 cites W2131247421 @default.
- W2765754570 cites W2140492247 @default.
- W2765754570 cites W2142621481 @default.
- W2765754570 cites W2142755326 @default.
- W2765754570 cites W2143653962 @default.
- W2765754570 cites W2146643436 @default.
- W2765754570 cites W2147318351 @default.
- W2765754570 cites W2148603666 @default.
- W2765754570 cites W2152286148 @default.
- W2765754570 cites W2155782265 @default.
- W2765754570 cites W2157045918 @default.
- W2765754570 cites W2159870332 @default.
- W2765754570 cites W2164207455 @default.
- W2765754570 cites W2165283316 @default.