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- W2765762287 abstract "The biology of nitric oxide (NO) is defined by the interactions of NO with hemoglobin (Hb). Specifically, the addition reaction in which NO purportedly binds irreversibly to unliganded hemes in Hb, and the oxidation reaction in which nitrate and methemoglobin are produced from the interaction of NO with oxyhemoglobin, have been widely viewed as the principal fates of NO in vivo. These reaction pathways, however, are difficult to reconcile with the activity of NO as endothelium-derived relaxing factor and, if dominant, dictate that NO consumption would far exceed production in vivo, in violation of a mass-balance constraint. This chapter reviews recent work from laboratories showing that NO addition and oxidation reactions, as operationally defined, are of secondary importance under physiological conditions. Instead, Hb recruits alternative reaction pathways with NO that preserve its bioactivity. The data shows that Hb conserves its NO while dispensing it selectively to maximize O 2 delivery in the respiratory cycle." @default.
- W2765762287 created "2017-11-10" @default.
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- W2765762287 date "2000-01-01" @default.
- W2765762287 modified "2023-09-26" @default.
- W2765762287 title "The Respiratory Cycle" @default.
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- W2765762287 doi "https://doi.org/10.1016/b978-012370420-7/50016-2" @default.
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