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- W2765791444 abstract "The pathophysiology of sickle cell disease (SCD) is dependent on the polymerization of deoxygenated sickle hemoglobin (HbS), leading to erythrocyte deformation (sickling) and vaso-occlusion within the microvasculature. Following deoxygenation, there is a delay time before polymerization is initiated, during which nucleation of HbS monomers occurs. An agent with the ability to extend this delay time or slow polymerization would therefore hold a therapeutic, possibly curative, potential. We used the Systematic Evolution of Ligands by Exponential Enrichment (SELEX) method to screen for HbS-binding RNA aptamers modified with nuclease-resistant 2′-fluoropyrimidines. Polymerization assays were employed to identify aptamers with polymerization-inhibitory properties. Two noncompeting aptamers, DE3A and OX3B, were found to bind hemoglobin, significantly increase the delay time, and reduce the rate of polymerization of HbS. These modifiable, nuclease-resistant aptamers are potential new therapeutic agents for SCD." @default.
- W2765791444 created "2017-11-10" @default.
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- W2765791444 date "2017-12-01" @default.
- W2765791444 modified "2023-10-17" @default.
- W2765791444 title "Identification of Aptamers That Bind to Sickle Hemoglobin and Inhibit Its Polymerization" @default.
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- W2765791444 doi "https://doi.org/10.1089/nat.2016.0646" @default.
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