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- W2765792934 endingPage "e0186469" @default.
- W2765792934 startingPage "e0186469" @default.
- W2765792934 abstract "Alopecia X is a hair cycle arrest disorder in Pomeranians. Histologically, kenogen and telogen hair follicles predominate, whereas anagen follicles are sparse. The induction of anagen relies on the activation of hair follicle stem cells and their subsequent proliferation and differentiation. Stem cell function depends on finely tuned interactions of signaling molecules and transcription factors, which are not well defined in dogs. We performed transcriptome profiling on skin biopsies to analyze altered molecular pathways in alopecia X. Biopsies from five affected and four non-affected Pomeranians were investigated. Differential gene expression revealed a downregulation of key regulator genes of the Wnt (CTNNB1, LEF1, TCF3, WNT10B) and Shh (SHH, GLI1, SMO, PTCH2) pathways. In mice it has been shown that Wnt and Shh signaling results in stem cell activation and differentiation Thus our findings are in line with the lack of anagen hair follicles in dogs with Alopecia X. We also observed a significant downregulation of the stem cell markers SOX9, LHX2, LGR5, TCF7L1 and GLI1 whereas NFATc1, a quiescence marker, was upregulated in alopecia X. Moreover, genes coding for enzymes directly involved in the sex hormone metabolism (CYP1A1, CYP1B1, HSD17B14) were differentially regulated in alopecia X. These findings are in agreement with the so far proposed but not yet proven deregulation of the sex hormone metabolism in this disease." @default.
- W2765792934 created "2017-11-10" @default.
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- W2765792934 date "2017-10-24" @default.
- W2765792934 modified "2023-10-16" @default.
- W2765792934 title "Novel insights into the pathways regulating the canine hair cycle and their deregulation in alopecia X" @default.
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- W2765792934 doi "https://doi.org/10.1371/journal.pone.0186469" @default.
- W2765792934 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5655477" @default.
- W2765792934 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29065140" @default.
- W2765792934 hasPublicationYear "2017" @default.
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