Matches in SemOpenAlex for { <https://semopenalex.org/work/W2765794957> ?p ?o ?g. }
- W2765794957 endingPage "93" @default.
- W2765794957 startingPage "82" @default.
- W2765794957 abstract "Pancreatic ductal adenocarcinoma (PDAC) is highly aggressive disease and current treatment regimens fail to effectively cure PDAC. Development of resistance to current therapy is one of the key reasons for this outcome. Nimbolide (NL), a triterpenoid obtained from Azadirachta indica, exhibits anticancer properties in various cancer including PDAC cells. However, the underlying mechanism of this anticancer agent in PDAC cells remains undefined. We show that NL exerts a higher level of apoptotic cell death compared to the first-line agent gemcitabine for PDAC, as well as other anticancer agents including sorafenib and curcumin. The anticancer efficacy of NL was further evidenced by a reduction in the CD44+ as well as cancer stem-like cell (CSC) population, as it causes decreased sphere formation. Mechanistically, the anticancer efficacy of NL associates with reduced mutant p53 as well as increased mitochondrial activity in the form of increased mitochondrial reactive oxygen species and mitochondrial mass. Together, this study highlights the therapeutic potential of NL in mutant p53 expressing pancreatic cancer." @default.
- W2765794957 created "2017-11-10" @default.
- W2765794957 creator A5010486479 @default.
- W2765794957 creator A5011054139 @default.
- W2765794957 creator A5012219857 @default.
- W2765794957 creator A5012502014 @default.
- W2765794957 creator A5033228095 @default.
- W2765794957 creator A5034579434 @default.
- W2765794957 creator A5051071188 @default.
- W2765794957 creator A5059138390 @default.
- W2765794957 creator A5062006629 @default.
- W2765794957 creator A5063116970 @default.
- W2765794957 creator A5070100515 @default.
- W2765794957 creator A5084318911 @default.
- W2765794957 date "2018-01-01" @default.
- W2765794957 modified "2023-09-28" @default.
- W2765794957 title "Nimbolide reduces CD44 positive cell population and induces mitochondrial apoptosis in pancreatic cancer cells" @default.
- W2765794957 cites W1491779959 @default.
- W2765794957 cites W1809723326 @default.
- W2765794957 cites W1880854925 @default.
- W2765794957 cites W1930516194 @default.
- W2765794957 cites W1931508686 @default.
- W2765794957 cites W1969681477 @default.
- W2765794957 cites W1975834732 @default.
- W2765794957 cites W1979403925 @default.
- W2765794957 cites W1981781914 @default.
- W2765794957 cites W1983457932 @default.
- W2765794957 cites W1991045666 @default.
- W2765794957 cites W1992514491 @default.
- W2765794957 cites W1992995822 @default.
- W2765794957 cites W1993238109 @default.
- W2765794957 cites W1995215542 @default.
- W2765794957 cites W2000605323 @default.
- W2765794957 cites W2003667906 @default.
- W2765794957 cites W2004446628 @default.
- W2765794957 cites W2005627263 @default.
- W2765794957 cites W2006936457 @default.
- W2765794957 cites W2012235333 @default.
- W2765794957 cites W2019264784 @default.
- W2765794957 cites W2022146354 @default.
- W2765794957 cites W2024326279 @default.
- W2765794957 cites W2026070762 @default.
- W2765794957 cites W2026362825 @default.
- W2765794957 cites W2028300044 @default.
- W2765794957 cites W2028865177 @default.
- W2765794957 cites W2034616899 @default.
- W2765794957 cites W2037961348 @default.
- W2765794957 cites W2039210293 @default.
- W2765794957 cites W2040740978 @default.
- W2765794957 cites W2042290667 @default.
- W2765794957 cites W2045246542 @default.
- W2765794957 cites W2046644128 @default.
- W2765794957 cites W2047318784 @default.
- W2765794957 cites W2047605904 @default.
- W2765794957 cites W2049137769 @default.
- W2765794957 cites W2050173108 @default.
- W2765794957 cites W2057428268 @default.
- W2765794957 cites W2061797905 @default.
- W2765794957 cites W2073095285 @default.
- W2765794957 cites W2077796580 @default.
- W2765794957 cites W2080232352 @default.
- W2765794957 cites W2081622541 @default.
- W2765794957 cites W2087790613 @default.
- W2765794957 cites W2088441464 @default.
- W2765794957 cites W2092084997 @default.
- W2765794957 cites W2096220505 @default.
- W2765794957 cites W2106787323 @default.
- W2765794957 cites W2111705409 @default.
- W2765794957 cites W2114843025 @default.
- W2765794957 cites W2115886860 @default.
- W2765794957 cites W2121992849 @default.
- W2765794957 cites W2122341467 @default.
- W2765794957 cites W2123250752 @default.
- W2765794957 cites W2128822546 @default.
- W2765794957 cites W2129269935 @default.
- W2765794957 cites W2131025996 @default.
- W2765794957 cites W2131415852 @default.
- W2765794957 cites W2131555383 @default.
- W2765794957 cites W2132834292 @default.
- W2765794957 cites W2135232251 @default.
- W2765794957 cites W2140765540 @default.
- W2765794957 cites W2149441684 @default.
- W2765794957 cites W2150144117 @default.
- W2765794957 cites W2152832279 @default.
- W2765794957 cites W2153661117 @default.
- W2765794957 cites W2153850374 @default.
- W2765794957 cites W2161769699 @default.
- W2765794957 cites W2162067282 @default.
- W2765794957 cites W2167291962 @default.
- W2765794957 cites W2168411134 @default.
- W2765794957 cites W2168584828 @default.
- W2765794957 cites W2170853272 @default.
- W2765794957 cites W2170922686 @default.
- W2765794957 cites W2176387555 @default.
- W2765794957 cites W2267444959 @default.
- W2765794957 cites W2271805342 @default.
- W2765794957 cites W2304346766 @default.
- W2765794957 cites W2312641146 @default.