FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2765798001> ?p ?o ?g. }

• W2765798001 endingPage "485" @default.
• W2765798001 startingPage "478" @default.
• W2765798001 abstract "A high number of human islets can be isolated by using modern purified tissue dissociation enzymes; however, this requires the use of >20 Wunsch units (WU)/g of pancreas for digestion. Attempts to reduce this dose have resulted in pancreas underdigestion and poor islet recovery but improved islet function. In this study, we achieved a high number of functional islets using a low dose of recombinant collagenase enzyme mixture (RCEM-1200 WU rC2 and 10 million collagen-degrading activity [CDA] U of rC1 containing about 209 mg of collagenase to digest a 100-g pancreas). The collagenase dose used in these isolations is about 42% of the natural collagenase enzyme mixture (NCEM) dose commonly used to digest a 100-g pancreas. Low-dose RCEM was efficient in digesting entire pancreases to obtain higher yield (5535 ± 830 and 2582 ± 925 islet equivalent/g, P < .05) and less undigested tissue (16.7 ± 5% and 37.8 ± 3%, P < .05) compared with low-dose NCEM (12WU/g). Additionally, low-dose RCEM islets retained better morphology (confirmed with scanning electron microscopy) and higher in vitro basal insulin release (2391 ± 1342 and 1778 ± 978 μU/mL; P < .05) compared with standard-dose NCEM. Nude mouse bioassay demonstrated better islet function for low-dose RCEM (area under the curve [AUC] 24 968) compared with low-dose (AUC-38 225) or standard-dose NCEM (AUC-38 685), P < .05. This is the first report indicating that islet function can be improved by using low-dose rC1rC2 (RCEM)." @default.
• W2765798001 created "2017-11-10" @default.
• W2765798001 creator A5007431205 @default.
• W2765798001 creator A5009856948 @default.
• W2765798001 creator A5010790598 @default.
• W2765798001 creator A5016444065 @default.
• W2765798001 creator A5028851017 @default.
• W2765798001 creator A5031500611 @default.
• W2765798001 creator A5050018548 @default.
• W2765798001 creator A5070104947 @default.
• W2765798001 creator A5072419465 @default.
• W2765798001 creator A5074172964 @default.
• W2765798001 creator A5089664464 @default.
• W2765798001 creator A5090507736 @default.
• W2765798001 creator A5090573860 @default.
• W2765798001 date "2018-02-01" @default.
• W2765798001 modified "2023-10-18" @default.
• W2765798001 title "Beneficial effect of recombinant rC1rC2 collagenases on human islet function: Efficacy of low-dose enzymes on pancreas digestion and yield" @default.
• W2765798001 cites W1548121400 @default.
• W2765798001 cites W1969730253 @default.
• W2765798001 cites W2001447612 @default.
• W2765798001 cites W2002192212 @default.
• W2765798001 cites W2008606334 @default.
• W2765798001 cites W2015081945 @default.
• W2765798001 cites W2020474241 @default.
• W2765798001 cites W2021214934 @default.
• W2765798001 cites W2032203942 @default.
• W2765798001 cites W2043222039 @default.
• W2765798001 cites W2069096201 @default.
• W2765798001 cites W2072784744 @default.
• W2765798001 cites W2074336129 @default.
• W2765798001 cites W2077556526 @default.
• W2765798001 cites W2092786211 @default.
• W2765798001 cites W2093237520 @default.
• W2765798001 cites W2164653018 @default.
• W2765798001 cites W2168687284 @default.
• W2765798001 cites W2171678230 @default.
• W2765798001 cites W2249498033 @default.
• W2765798001 cites W2331768284 @default.
• W2765798001 cites W2341414956 @default.
• W2765798001 cites W2528516704 @default.
• W2765798001 cites W2539044895 @default.
• W2765798001 cites W2554650020 @default.
• W2765798001 cites W2595945237 @default.
• W2765798001 cites W2790036124 @default.
• W2765798001 cites W783049571 @default.
• W2765798001 doi "https://doi.org/10.1111/ajt.14542" @default.
• W2765798001 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29044985" @default.
• W2765798001 hasPublicationYear "2018" @default.
• W2765798001 type Work @default.
• W2765798001 sameAs 2765798001 @default.
• W2765798001 citedByCount "13" @default.
• W2765798001 countsByYear W27657980012018 @default.
• W2765798001 countsByYear W27657980012019 @default.
• W2765798001 countsByYear W27657980012020 @default.
• W2765798001 countsByYear W27657980012021 @default.
• W2765798001 countsByYear W27657980012022 @default.
• W2765798001 crossrefType "journal-article" @default.
• W2765798001 hasAuthorship W2765798001A5007431205 @default.
• W2765798001 hasAuthorship W2765798001A5009856948 @default.
• W2765798001 hasAuthorship W2765798001A5010790598 @default.
• W2765798001 hasAuthorship W2765798001A5016444065 @default.
• W2765798001 hasAuthorship W2765798001A5028851017 @default.
• W2765798001 hasAuthorship W2765798001A5031500611 @default.
• W2765798001 hasAuthorship W2765798001A5050018548 @default.
• W2765798001 hasAuthorship W2765798001A5070104947 @default.
• W2765798001 hasAuthorship W2765798001A5072419465 @default.
• W2765798001 hasAuthorship W2765798001A5074172964 @default.
• W2765798001 hasAuthorship W2765798001A5089664464 @default.
• W2765798001 hasAuthorship W2765798001A5090507736 @default.
• W2765798001 hasAuthorship W2765798001A5090573860 @default.
• W2765798001 hasBestOaLocation W27657980011 @default.
• W2765798001 hasConcept C134018914 @default.
• W2765798001 hasConcept C136229726 @default.
• W2765798001 hasConcept C165220095 @default.
• W2765798001 hasConcept C181199279 @default.
• W2765798001 hasConcept C2778394429 @default.
• W2765798001 hasConcept C2778764654 @default.
• W2765798001 hasConcept C2779306644 @default.
• W2765798001 hasConcept C55493867 @default.
• W2765798001 hasConcept C71924100 @default.
• W2765798001 hasConcept C86803240 @default.
• W2765798001 hasConceptScore W2765798001C134018914 @default.
• W2765798001 hasConceptScore W2765798001C136229726 @default.
• W2765798001 hasConceptScore W2765798001C165220095 @default.
• W2765798001 hasConceptScore W2765798001C181199279 @default.
• W2765798001 hasConceptScore W2765798001C2778394429 @default.
• W2765798001 hasConceptScore W2765798001C2778764654 @default.
• W2765798001 hasConceptScore W2765798001C2779306644 @default.
• W2765798001 hasConceptScore W2765798001C55493867 @default.
• W2765798001 hasConceptScore W2765798001C71924100 @default.
• W2765798001 hasConceptScore W2765798001C86803240 @default.
• W2765798001 hasIssue "2" @default.
• W2765798001 hasLocation W27657980011 @default.
• W2765798001 hasLocation W27657980012 @default.
• W2765798001 hasOpenAccess W2765798001 @default.
• W2765798001 hasPrimaryLocation W27657980011 @default.
• W2765798001 hasRelatedWork W1502308402 @default.

• next