Matches in SemOpenAlex for { <https://semopenalex.org/work/W2765839013> ?p ?o ?g. }
- W2765839013 endingPage "12895" @default.
- W2765839013 startingPage "12888" @default.
- W2765839013 abstract "We report here the concept of a self-powered, target-triggered DNA motor constructed by engineering a DNAzyme to adapt into binding-induced DNA assembly. An affinity ligand was attached to the DNAzyme motor via a DNA spacer, and a second affinity ligand was conjugated to the gold nanoparticle (AuNP) that was also decorated with hundreds of substrate strands serving as a high-density, three-dimensional track for the DNAzyme motor. Binding of a target molecule to the two ligands induced hybridization between the DNAzyme and its substrate on the AuNP, which are otherwise unable to spontaneously hybridize. The hybridization of DNAzyme with the substrate initiates the cleavage of the substrate and the autonomous movement of the DNAzyme along the AuNP. Each moving step restores the fluorescence of a dye molecule, enabling monitoring of the operation of the DNAzyme motor in real time. A simple addition or depletion of the cofactor Mg2+ allows for fine control of the DNAzyme motor. The motor can translate a single binding event into cleavage of hundreds of substrates, enabling amplified detection of proteins at room temperature without the need for separation." @default.
- W2765839013 created "2017-11-10" @default.
- W2765839013 creator A5015876994 @default.
- W2765839013 creator A5031552785 @default.
- W2765839013 creator A5039449480 @default.
- W2765839013 creator A5050393620 @default.
- W2765839013 creator A5052541540 @default.
- W2765839013 creator A5071428253 @default.
- W2765839013 date "2017-11-03" @default.
- W2765839013 modified "2023-10-11" @default.
- W2765839013 title "A Target-Triggered DNAzyme Motor Enabling Homogeneous, Amplified Detection of Proteins" @default.
- W2765839013 cites W1631110814 @default.
- W2765839013 cites W1964723252 @default.
- W2765839013 cites W1978809492 @default.
- W2765839013 cites W1987911559 @default.
- W2765839013 cites W1988749907 @default.
- W2765839013 cites W1989158995 @default.
- W2765839013 cites W1989813275 @default.
- W2765839013 cites W1991159148 @default.
- W2765839013 cites W1993933078 @default.
- W2765839013 cites W1999345881 @default.
- W2765839013 cites W2005025782 @default.
- W2765839013 cites W2011967594 @default.
- W2765839013 cites W2014065088 @default.
- W2765839013 cites W2055148200 @default.
- W2765839013 cites W2059158601 @default.
- W2765839013 cites W2068236479 @default.
- W2765839013 cites W2076269475 @default.
- W2765839013 cites W2079284567 @default.
- W2765839013 cites W2084798466 @default.
- W2765839013 cites W2085277047 @default.
- W2765839013 cites W2086654802 @default.
- W2765839013 cites W2090233918 @default.
- W2765839013 cites W2092956762 @default.
- W2765839013 cites W2096526911 @default.
- W2765839013 cites W2143650625 @default.
- W2765839013 cites W2146238633 @default.
- W2765839013 cites W2153700418 @default.
- W2765839013 cites W2158778875 @default.
- W2765839013 cites W2162538509 @default.
- W2765839013 cites W2165989613 @default.
- W2765839013 cites W2259212906 @default.
- W2765839013 cites W2260707719 @default.
- W2765839013 cites W2287650212 @default.
- W2765839013 cites W2314476344 @default.
- W2765839013 cites W2317330415 @default.
- W2765839013 cites W2318658461 @default.
- W2765839013 cites W2334139659 @default.
- W2765839013 cites W2410571510 @default.
- W2765839013 cites W2539022142 @default.
- W2765839013 cites W2594377120 @default.
- W2765839013 cites W2608421778 @default.
- W2765839013 cites W2625437134 @default.
- W2765839013 cites W4211177570 @default.
- W2765839013 cites W4236617407 @default.
- W2765839013 cites W4240312877 @default.
- W2765839013 doi "https://doi.org/10.1021/acs.analchem.7b03529" @default.
- W2765839013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29099172" @default.
- W2765839013 hasPublicationYear "2017" @default.
- W2765839013 type Work @default.
- W2765839013 sameAs 2765839013 @default.
- W2765839013 citedByCount "111" @default.
- W2765839013 countsByYear W27658390132017 @default.
- W2765839013 countsByYear W27658390132018 @default.
- W2765839013 countsByYear W27658390132019 @default.
- W2765839013 countsByYear W27658390132020 @default.
- W2765839013 countsByYear W27658390132021 @default.
- W2765839013 countsByYear W27658390132022 @default.
- W2765839013 countsByYear W27658390132023 @default.
- W2765839013 crossrefType "journal-article" @default.
- W2765839013 hasAuthorship W2765839013A5015876994 @default.
- W2765839013 hasAuthorship W2765839013A5031552785 @default.
- W2765839013 hasAuthorship W2765839013A5039449480 @default.
- W2765839013 hasAuthorship W2765839013A5050393620 @default.
- W2765839013 hasAuthorship W2765839013A5052541540 @default.
- W2765839013 hasAuthorship W2765839013A5071428253 @default.
- W2765839013 hasBestOaLocation W27658390131 @default.
- W2765839013 hasConcept C111368507 @default.
- W2765839013 hasConcept C12554922 @default.
- W2765839013 hasConcept C127313418 @default.
- W2765839013 hasConcept C127413603 @default.
- W2765839013 hasConcept C160408235 @default.
- W2765839013 hasConcept C171250308 @default.
- W2765839013 hasConcept C175156509 @default.
- W2765839013 hasConcept C185592680 @default.
- W2765839013 hasConcept C187320778 @default.
- W2765839013 hasConcept C19014433 @default.
- W2765839013 hasConcept C192562407 @default.
- W2765839013 hasConcept C21951064 @default.
- W2765839013 hasConcept C2777289219 @default.
- W2765839013 hasConcept C43369102 @default.
- W2765839013 hasConcept C552990157 @default.
- W2765839013 hasConcept C55493867 @default.
- W2765839013 hasConcept C84211826 @default.
- W2765839013 hasConcept C86803240 @default.
- W2765839013 hasConceptScore W2765839013C111368507 @default.
- W2765839013 hasConceptScore W2765839013C12554922 @default.
- W2765839013 hasConceptScore W2765839013C127313418 @default.