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- W2765846835 abstract "Abstract Activation of specific sets of protein kinases by intracellular signal molecules has become more and more apparent in the past decade. Phosphorylation, one of key posttranslational modification events, is activated by kinase or regulatory protein and is vital for controlling many physiological functions of eukaryotic cells such as cell proliferation, differentiation, malignant transformation, and signal transduction mediated by external stimuli. Moreovers, the reversible modification of phosphorylation and dephosphorylation can result in different features of the target substrate molecules including DNA binding, protein-protein interaction, subcellular location and enzymatic activity, and is often hijacked by viral infection. Epstein-Barr virus (EBV) and Kaposi’s sarcomaassociated herpesvirus (KSHV), two human oncogenic gamma-herpesviruses, are shown to tightly associate with many malignancies. In this review, we summarize the recent progresses on understanding of molecular properties and regulatory modes of cellular and viral proteins phosphorylation influenced by these two tumor viruses, and highlight the potential therapeutic targets and strategies against their related cancers." @default.
- W2765846835 created "2017-11-10" @default.
- W2765846835 creator A5018574040 @default.
- W2765846835 creator A5037954928 @default.
- W2765846835 creator A5038825816 @default.
- W2765846835 creator A5070616314 @default.
- W2765846835 creator A5071309906 @default.
- W2765846835 creator A5080810870 @default.
- W2765846835 date "2017-10-01" @default.
- W2765846835 modified "2023-10-04" @default.
- W2765846835 title "The regulatory role of protein phosphorylation in human gammaherpesvirus associated cancers" @default.
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