FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2765848885> ?p ?o ?g. }

• W2765848885 endingPage "191" @default.
• W2765848885 startingPage "171" @default.
• W2765848885 abstract "The stiffness of a cell’s microenvironment influences its behavior. Testing the effect of stiffness, or elasticity, on tumor cell behavior requires a matrix that provides the integrin binding sites that are found in stroma. Collagen I is a major component of stroma and allows integrin binding, but when it is reconstituted after extraction and solubilization, it is difficult to work with and too soft to model tumor tissue. Although the stiffness of collagen I matrices can be adjusted by changing collagen concentration, doing so also affects the number of integrin binding sites available to cells, confounding experimental variables. The goal of this work was to tune collagen I matrices over a range of elasticities (1–6 kPa) relevant for modeling normal and tumorous breast tissue, without altering the density of cell-matrix ligands. This was accomplished by functionalizing collagen I with glycidyl methacrylate (GMA), and using lithium acylphosphinate (LAP) as a photoinitiator of GMA cross-linking. Cross-links were photoactivated by irradiating the GMA-functionalized collagen at 365 nm for 2 min or less (4.4 mW/cm2). Breast cancer cells (MDA-MB-231) survived and migrated on these matrices. Collagen I-GMA gels can be used to ascertain how varying extracellular matrix elasticity affects breast cancer cell behavior." @default.
• W2765848885 created "2017-11-10" @default.
• W2765848885 creator A5010611714 @default.
• W2765848885 creator A5034380797 @default.
• W2765848885 creator A5049417662 @default.
• W2765848885 creator A5050252470 @default.
• W2765848885 creator A5076661635 @default.
• W2765848885 date "2017-10-21" @default.
• W2765848885 modified "2023-09-26" @default.
• W2765848885 title "Stiffness-Tuned Matrices for Tumor Cell Studies" @default.
• W2765848885 cites W1486529190 @default.
• W2765848885 cites W1526243437 @default.
• W2765848885 cites W1568678994 @default.
• W2765848885 cites W1587510658 @default.
• W2765848885 cites W1970226578 @default.
• W2765848885 cites W1971635936 @default.
• W2765848885 cites W1975132186 @default.
• W2765848885 cites W1976842528 @default.
• W2765848885 cites W1980199136 @default.
• W2765848885 cites W1984724534 @default.
• W2765848885 cites W1986343904 @default.
• W2765848885 cites W1989752993 @default.
• W2765848885 cites W1992282855 @default.
• W2765848885 cites W1995388182 @default.
• W2765848885 cites W1998274452 @default.
• W2765848885 cites W1999848701 @default.
• W2765848885 cites W2017851692 @default.
• W2765848885 cites W2021750913 @default.
• W2765848885 cites W2024250498 @default.
• W2765848885 cites W2024791310 @default.
• W2765848885 cites W2025663995 @default.
• W2765848885 cites W2043443402 @default.
• W2765848885 cites W2055331593 @default.
• W2765848885 cites W2057293043 @default.
• W2765848885 cites W2059093040 @default.
• W2765848885 cites W2059731807 @default.
• W2765848885 cites W2063682786 @default.
• W2765848885 cites W2067078717 @default.
• W2765848885 cites W2071557920 @default.
• W2765848885 cites W2077833708 @default.
• W2765848885 cites W2079473466 @default.
• W2765848885 cites W2081910439 @default.
• W2765848885 cites W2082877303 @default.
• W2765848885 cites W2086244192 @default.
• W2765848885 cites W2089687846 @default.
• W2765848885 cites W2090052898 @default.
• W2765848885 cites W2099052265 @default.
• W2765848885 cites W2100303404 @default.
• W2765848885 cites W2106324055 @default.
• W2765848885 cites W2106977857 @default.
• W2765848885 cites W2108832165 @default.
• W2765848885 cites W2118180691 @default.
• W2765848885 cites W2119063676 @default.
• W2765848885 cites W2121933066 @default.
• W2765848885 cites W2124428587 @default.
• W2765848885 cites W2127471027 @default.
• W2765848885 cites W2132566055 @default.
• W2765848885 cites W2133135568 @default.
• W2765848885 cites W2134208433 @default.
• W2765848885 cites W2148328620 @default.
• W2765848885 cites W2157484111 @default.
• W2765848885 cites W2161162374 @default.
• W2765848885 cites W2163060364 @default.
• W2765848885 cites W2163184722 @default.
• W2765848885 cites W2169164974 @default.
• W2765848885 cites W2503071603 @default.
• W2765848885 doi "https://doi.org/10.1007/978-3-319-60511-1_9" @default.
• W2765848885 hasPublicationYear "2017" @default.
• W2765848885 type Work @default.
• W2765848885 sameAs 2765848885 @default.
• W2765848885 citedByCount "0" @default.
• W2765848885 crossrefType "book-chapter" @default.
• W2765848885 hasAuthorship W2765848885A5010611714 @default.
• W2765848885 hasAuthorship W2765848885A5034380797 @default.
• W2765848885 hasAuthorship W2765848885A5049417662 @default.
• W2765848885 hasAuthorship W2765848885A5050252470 @default.
• W2765848885 hasAuthorship W2765848885A5076661635 @default.
• W2765848885 hasConcept C106487976 @default.
• W2765848885 hasConcept C121854251 @default.
• W2765848885 hasConcept C12554922 @default.
• W2765848885 hasConcept C136229726 @default.
• W2765848885 hasConcept C1491633281 @default.
• W2765848885 hasConcept C159985019 @default.
• W2765848885 hasConcept C185592680 @default.
• W2765848885 hasConcept C189165786 @default.
• W2765848885 hasConcept C192562407 @default.
• W2765848885 hasConcept C195687474 @default.
• W2765848885 hasConcept C2779372316 @default.
• W2765848885 hasConcept C2780801859 @default.
• W2765848885 hasConcept C44228677 @default.
• W2765848885 hasConcept C521977710 @default.
• W2765848885 hasConcept C55493867 @default.
• W2765848885 hasConcept C71924100 @default.
• W2765848885 hasConcept C86803240 @default.
• W2765848885 hasConceptScore W2765848885C106487976 @default.
• W2765848885 hasConceptScore W2765848885C121854251 @default.
• W2765848885 hasConceptScore W2765848885C12554922 @default.
• W2765848885 hasConceptScore W2765848885C136229726 @default.

• next