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- W2765851812 endingPage "287" @default.
- W2765851812 startingPage "279" @default.
- W2765851812 abstract "Host-bacterial interactions at mucosal surfaces require recognition of the bacteria by host cells enabling targeted responses to maintain tissue homeostasis. It is now well recognized that an array of host-derived pattern recognition receptors (PRRs), both cell-bound and soluble, are critical to innate immune engagement of microbes via microbial-associated molecular patterns (MAMP). This report describes the use of a nonhuman primate model to evaluate changes in the expression of these sensing molecules related to aging in healthy gingival tissues. Macaca mulatta aged 3–24 years were evaluated clinically and gingival tissues obtained, RNA isolated and microarray analysis conducted for gene expression of the sensing pattern recognition receptors (PRRs). The results demonstrated increased expression of various PRRs in healthy aging gingiva including extracellular (CD14, CD209, CLEC4E, TLR4), intracellular (NAIP, IFIH1, DAI) and soluble (PTX4, SAA1) PRRs. Selected PRRs were also correlated with both bleeding on probing (BOP) and pocket depth (PD) in the animals. These findings suggest that aged animals express altered levels of various PRRs that could affect the ability of the tissues to interact effectively with the juxtaposed microbial ecology, presumably contributing to an enhanced risk of periodontitis even in clinically healthy oral mucosal tissues with aging." @default.
- W2765851812 created "2017-11-10" @default.
- W2765851812 creator A5008467044 @default.
- W2765851812 creator A5009163664 @default.
- W2765851812 creator A5011073600 @default.
- W2765851812 creator A5013096129 @default.
- W2765851812 creator A5026571547 @default.
- W2765851812 creator A5057872977 @default.
- W2765851812 creator A5066222269 @default.
- W2765851812 creator A5067935460 @default.
- W2765851812 date "2018-03-01" @default.
- W2765851812 modified "2023-10-17" @default.
- W2765851812 title "Comparative analysis of microbial sensing molecules in mucosal tissues with aging" @default.
- W2765851812 cites W1555278976 @default.
- W2765851812 cites W1589221135 @default.
- W2765851812 cites W1599928841 @default.
- W2765851812 cites W1604954631 @default.
- W2765851812 cites W1605416285 @default.
- W2765851812 cites W1672688094 @default.
- W2765851812 cites W1747197150 @default.
- W2765851812 cites W1876722732 @default.
- W2765851812 cites W1916529790 @default.
- W2765851812 cites W1919531331 @default.
- W2765851812 cites W1967535998 @default.
- W2765851812 cites W1968377406 @default.
- W2765851812 cites W1977179460 @default.
- W2765851812 cites W1977275248 @default.
- W2765851812 cites W1977836134 @default.
- W2765851812 cites W1981601846 @default.
- W2765851812 cites W1986181335 @default.
- W2765851812 cites W1994080141 @default.
- W2765851812 cites W2001488960 @default.
- W2765851812 cites W2004740947 @default.
- W2765851812 cites W2008415419 @default.
- W2765851812 cites W2009034382 @default.
- W2765851812 cites W2012129075 @default.
- W2765851812 cites W2019323104 @default.
- W2765851812 cites W2021838232 @default.
- W2765851812 cites W2021995791 @default.
- W2765851812 cites W2023323209 @default.
- W2765851812 cites W2027143708 @default.
- W2765851812 cites W2027552314 @default.
- W2765851812 cites W2029029756 @default.
- W2765851812 cites W2032293995 @default.
- W2765851812 cites W2033726221 @default.
- W2765851812 cites W2034503638 @default.
- W2765851812 cites W2036054262 @default.
- W2765851812 cites W2037582642 @default.
- W2765851812 cites W2040163024 @default.
- W2765851812 cites W2040701593 @default.
- W2765851812 cites W2041489554 @default.
- W2765851812 cites W2043504114 @default.
- W2765851812 cites W2044132116 @default.
- W2765851812 cites W2045068030 @default.
- W2765851812 cites W2045278877 @default.
- W2765851812 cites W2045770763 @default.
- W2765851812 cites W2059106230 @default.
- W2765851812 cites W2063534715 @default.
- W2765851812 cites W2065915806 @default.
- W2765851812 cites W2067359484 @default.
- W2765851812 cites W2071543540 @default.
- W2765851812 cites W2071670416 @default.
- W2765851812 cites W2073346527 @default.
- W2765851812 cites W2074963908 @default.
- W2765851812 cites W2076498636 @default.
- W2765851812 cites W2077550407 @default.
- W2765851812 cites W2078239945 @default.
- W2765851812 cites W2079174060 @default.
- W2765851812 cites W2079444845 @default.
- W2765851812 cites W2082402714 @default.
- W2765851812 cites W2085720307 @default.
- W2765851812 cites W2085999401 @default.
- W2765851812 cites W2088290323 @default.
- W2765851812 cites W2093053402 @default.
- W2765851812 cites W2099470584 @default.
- W2765851812 cites W2104465828 @default.
- W2765851812 cites W2104544944 @default.
- W2765851812 cites W2105779796 @default.
- W2765851812 cites W2106248075 @default.
- W2765851812 cites W2113476651 @default.
- W2765851812 cites W2114769428 @default.
- W2765851812 cites W2125845521 @default.
- W2765851812 cites W2126552441 @default.
- W2765851812 cites W2127335466 @default.
- W2765851812 cites W2130413728 @default.
- W2765851812 cites W2132594700 @default.
- W2765851812 cites W2141141988 @default.
- W2765851812 cites W2143516276 @default.
- W2765851812 cites W2147738968 @default.
- W2765851812 cites W2154027181 @default.
- W2765851812 cites W2156267811 @default.
- W2765851812 cites W2159064971 @default.
- W2765851812 cites W2160832259 @default.
- W2765851812 cites W2160896781 @default.
- W2765851812 cites W2163167045 @default.
- W2765851812 cites W2163436443 @default.
- W2765851812 cites W39474405 @default.
- W2765851812 doi "https://doi.org/10.1016/j.imbio.2017.10.034" @default.