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• W2765853935 abstract "Tumor cell can be significantly influenced by various chemical groups of the extracellular matrix proteins. However, the underlying molecular mechanisms involved in the interaction between cancer cells and functional groups in the extracellular matrix remain unknown. Using chemically modified surfaces with biological functional groups (CH 3 , NH 2 , OH), it was found that hydrophobic surfaces modified with CH 3 and NH 2 suppressed cell proliferation and induced the number of apoptotic cells. Mitochondrial dysfunction, cytochrome c release, Bax upregulation, cleaved caspase-3 and PARP, and Bcl-2 downregulation indicated that hydrophobic surfaces with CH 3 and NH 2 triggered the activation of intrinsic apoptotic signaling pathway. Cells on the CH 3 - and NH 2 -modified hydrophobic surfaces showed downregulated expression and activation of integrin β1, with a subsequent decrease of focal adhesion kinase (FAK) activity. The RhoA/ROCK/PTEN signaling was then activated to inhibit the phosphorylation of PI3K and AKT, which are essential for cell proliferation. However, pretreatment of MDA-MB-231 cells with SF1670, a PTEN inhibitor, abolished the hydrophobic surface-induced activation of the intrinsic pathway. Taken together, the present results indicate that CH 3 - and NH 2 -modified hydrophobic surfaces induce mitochondria-mediated apoptosis by suppressing the PTEN/PI3K/AKT pathway, but not OH surfaces. These findings are helpful to understand the interaction between extracellular matrix and cancer cells, which might provide new insights into the mechanism potential intervention strategies for tumor prognosis. • Hydrophobic surfaces modified with CH3 and NH2 suppress cell proliferation with a decline of cyclin D1. • CH 3 - and NH 2 - modified surfaces induce mitochondria-mediated apoptosis of breast cancer cells via PTEN/PI3K/AKT pathway. • Hydrophobic surfaces downregulate filopodia formation and focal adhesion signaling. • PTEN inhibition abolishes the hydrophobic surface-induced cancer cells apoptosis." @default.
• W2765853935 created "2017-11-10" @default.
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• W2765853935 date "2018-01-01" @default.
• W2765853935 modified "2023-10-17" @default.
• W2765853935 title "Surface chemistry induces mitochondria-mediated apoptosis of breast cancer cells via PTEN/PI3K/AKT signaling pathway" @default.
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• W2765853935 doi "https://doi.org/10.1016/j.bbamcr.2017.10.007" @default.
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