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• W2765867519 abstract "Abstract Obesity affects gene expression and metabolism of white adipose tissue (WAT), which results in insulin resistance (IR) and type 2 diabetes. However, WAT is a heterogeneous organ containing many cell types that might respond differently to obesity-induced changes. We performed flow cytometry sorting and RNA expression profiling by microarray of major WAT cell types (adipocytes, CD45−/CD31−/CD34+ progenitors, CD45+/CD14+ monocytes/ macrophages, CD45+/CD14− leukocytes), which allowed us to identify genes enriched in specific cell fractions. Additionally, we included adipocytes and adipocyte progenitor cells obtained from lean and obese individuals. Taken together, we provide a detailed gene expression atlas of major human adipose tissue resident cell types for clinical/basic research and using this dataset provide lists of cell-type specific genes that are of interest for metabolic research." @default.
• W2765867519 created "2017-11-10" @default.
• W2765867519 creator A5022365583 @default.
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• W2765867519 date "2017-10-31" @default.
• W2765867519 modified "2023-10-18" @default.
• W2765867519 title "The cell-type specific transcriptome in human adipose tissue and influence of obesity on adipocyte progenitors" @default.
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• W2765867519 doi "https://doi.org/10.1038/sdata.2017.164" @default.
• W2765867519 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5663208" @default.
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