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• W2765877165 abstract "// Feng Guan 1 , Liang Wang 1 , Shuyu Hao 1 , Zhen Wu 1 , Jian Bai 2 , Zhuang Kang 3 , Quan Zhou 4 , Hong Chang 4 , Hui Yin 5 , Da Li 1 , Kaibin Tian 1 , Junpeng Ma 1 , Guijun Zhang 1 and Junting Zhang 1 1 Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China 2 CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China 3 Department of Glioma, Beijing Shijitan Hospital, Capital Medical University, Beijing, China 4 Department of Pathology, Beijing Shijitan Hospital, Capital Medical University, Beijing, China 5 Department of Social Medicine and Health Education, School of Public Health, Peking University, Beijing, China Correspondence to: Junting Zhang, email: zhangjunting2013@yahoo.com Keywords: retinol dehydrogenase 10 (RDH10); glioma; the cancer genome atlas (TCGA); tumor necrosis factor-like weak inducer of apoptosis (TWEAK); nuclear factor kapaB (NF-κB) Received: February 09, 2017      Accepted: September 25, 2017      Published: October 27, 2017 ABSTRACT Retinol dehydrogenase-10 (RDH10) is a member of the short-chain dehydrogenase/reductase family, which plays an important role in retinoic acid (RA) synthesis. Here, we show that RDH10 is highly expressed in human gliomas, and its expression correlates with tumor grade and patient survival times. In vitro , lentivirus-mediated shRNA knockdown of RDH10 suppressed glioma cell proliferation, survival, and invasiveness and cell cycle progression. In vivo , RDH10 knockdown reduced glioma growth in nude mice. Microarray analysis revealed that RDH10 silencing reduces expression of TNFRSF12A (Fn14), TNFSF12 (TWEAK), TRAF3, IKBKB (IKK-β), and BMPR2, while it increases expression of TRAF1, NFKBIA (IκBα), NFKBIE (IκBε), and TNFAIP3. This suggests that RDH10 promotes glioma cell proliferation and survival by regulating the TWEAK-NF-κB axis, and that it could potentially serve as a novel target for human glioma treatment." @default.
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• W2765877165 date "2017-10-27" @default.
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• W2765877165 title "Retinol dehydrogenase-10 promotes development and progression of human glioma via the TWEAK-NF-κB axis" @default.
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• W2765877165 doi "https://doi.org/10.18632/oncotarget.22166" @default.
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