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• W2765887310 abstract "SESSION TITLE: Lung Pathology 3 SESSION TYPE: Affiliate Case Report Poster PRESENTED ON: Tuesday, October 31, 2017 at 01:30 PM - 02:30 PM INTRODUCTION: Pulmonary calcinosis and pulmonary alveolar microlithiasis are metabolic lung processes commonly associated with end-stage renal disease. Relation to end-stage renal disease is more common with the latter. Pulmonary calcinosis however, presents with distinct interstitial characteristics of the lung parenchyma including caclium depostion in the basement membrane. It is commonly associated with other disorders such as: sarcoidosis, hyperparathyroidism, and can occur following renal or liver transplant. The early diagnosis of pulmonary calcinosis can prove to be beneficial as it is often asymptomatic, but can potentially progress to respiratory failure. CASE PRESENTATION: We present a case of a 71 year-old male with past medical history of asthma. He also had a nephrectomy in the past for unknown reasons. He presented to the emergency department with dyspnea and bilateral lower extremity edema. Results of pulmonary-function tests revelaed fixed obstruction and a slight diffusion impairment which was initally labelled as asthma. Computed tomography showed extensive microcalcifications consistent with either pulmonary alveolar microlithiasis or diffuse pulmonary calcinosis. It is more common for pulmonary alveolar microlithiasis to cause a restrictive disease and is usually seen in patients with chronic kidney disease. Therefore, this case is thought to be a presentation suggesting a diagnosis of pulmonary calcinosis. DISCUSSION: An abnormality in calcium metabolism is the basis of the pathophysiology behind the development of diffuse pulmonary calcinosis. Most often, presenting patients have had no prior lung damage and can be otherwsie asymptomatic. Respiratory insufficency ensues when severe alveolar-capillary damge accurs due to calcium deposition in the alveolar septae. Physical exam findings and chest radiograph may suggest heart failure and pulmonary edema as the culprit. In the correct clinical setting, such as chronic renal failure, the possibility of pulmonary calcinosis must be taken into consideration. As approriate diagnosis is necessary to provide adequate treatment for this reversable yet potentialy lethal lung condition. CONCLUSIONS: There are very few cases of pulmonary calcinosis in the recent literature. While usually asymptomatic, if symptoms do arise, treatment strategies need to be implemented to prevent worsening of condition. Reference #1: Belem, LC., Zanetti, G., et al. Metastatic pulmonary calcification: State-of-the-art review focused on imaging findings. Respiratory Medicine (2014) 108, 668-676 DISCLOSURE: The following authors have nothing to disclose: Kevin Charles, Kevin Langlois, Baljit Gill, Matthew Raley, Ashley Ferraro No Product/Research Disclosure Information" @default.
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• W2765887310 date "2017-10-01" @default.
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• W2765887310 title "Pulmonary Calcinosis vs Pulmonary Alveolar Microlithiasis: Can One Differentiate the Two" @default.
• W2765887310 doi "https://doi.org/10.1016/j.chest.2017.08.751" @default.
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